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AZD3409

 
National Institutes of Health

Papers overview

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2010
2010
PurposeAZD3409 is a novel DPTI that has potent activity against both FTase and GGTase-1. The in vitro inhibition profile of… Expand
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2008
2008
AZD3409 is an orally active double prodrug that was developed as a novel dual prenyltransferase inhibitor. The formation of the… Expand
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2008
2008
The aim of the present investigation is to develop a simple, fast, and sensitive method for the determination of a new candidate… Expand
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2006
2006
AKT and MAPK signaling are involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib. RAS… Expand
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2006
2006
Mutations at the H-, N-, and K-ras loci are among the most frequent genetic alterations in human cancers. In this study, we have… Expand
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2006
2006
BACKGROUND The antineoplastic activity of AZD3409 was evaluated in relation to paclitaxel in human breast (MDA-MB-231, BT-474… Expand
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Review
2005
Review
2005
The therapeutic utility of trastuzumab ('Herceptin') in breast cancer patients with tumours that overexpress erbB2 established… Expand
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2004
2004
3172 Background: AZD3409 is a novel, oral, antitumor agent that acts as a prenyl transferase inhibitor. It has potentially broad… Expand
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2004
2004
4744 Background: Prostate cancer is the most common malignancy in men with a predilection to metastasize to the bone. There is a… Expand
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2004
2004
3177 Background: AZD3409 is a novel, oral prenyl transferase inhibitor that has potential broad antitumor activity both as… Expand
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