AZD3409
National Institutes of Health
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PurposeAZD3409 is a novel DPTI that has potent activity against both FTase and GGTase-1. The in vitro inhibition profile of…
Microextraction in packed syringe (MEPS) as a rapid sample preparation method to handle unstable compounds in a complex matrix…
Mutations at the H-, N-, and K-ras loci are among the most frequent genetic alterations in human cancers. In this study, we have…
BACKGROUND
The antineoplastic activity of AZD3409 was evaluated in relation to paclitaxel in human breast (MDA-MB-231, BT-474…
Biological effectiveness is an important parameter in determining optimal dosages of molecular targeted drugs, such as farnesyl…
3172 Background: AZD3409 is a novel, oral, antitumor agent that acts as a prenyl transferase inhibitor. It has potentially broad…
3177 Background: AZD3409 is a novel, oral prenyl transferase inhibitor that has potential broad antitumor activity both as…