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AZD1446
National Institutes of Health
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2014
2014
Population pharmacokinetics and safety of AZD1446, a neuronal nicotinic receptor agonist, administered in healthy volunteers
Emma Boström
,
K. Bohnstedt
,
+6 authors
S. Lindholm
Clinical pharmacology in drug development
2014
Corpus ID: 842139
AZD1446 is a highly selective agonist of central α4β2 and α2β2 neuronal nicotinic receptors. The compound has been shown to…
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2012
2012
Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.
A. Mazurov
,
L. Miao
,
+13 authors
D. Yohannes
Journal of Medicinal Chemistry
2012
Corpus ID: 207229593
Diversification of essential nicotinic cholinergic pharmacophoric elements, i.e., cationic center and hydrogen bond acceptor…
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