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AZD1208

Known as: AZD 1208., AZD-1208, pan-PIM Kinase Inhibitor AZD1208 
An orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan-PIM kinase inhibitor AZD1208 inhibits the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies. Here we identified increased copy number… Expand
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2016
2016
The PIM family of proteins encodes serine/threonine kinases with important roles in protein synthesis and cancer cell metabolism… Expand
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2016
2016
Human T-cell leukemia virus type 1 (HTLV-1)-associated adult T-cell leukemia and T-cell lymphoma (ATL) are aggressive diseases… Expand
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2016
2016
Abstract Pim kinases phosphorylate and regulate a number of key acute myeloid leukemia (AML) cell survival proteins, and Pim… Expand
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2015
2015
BACKGROUND PIM1 kinase is coexpressed with c-MYC in human prostate cancers (PCs) and dramatically enhances c-MYC-induced… Expand
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2015
2015
Mammalian target of rapamycin (mTOR) signaling is a critical pathway in the biology of acute myeloid leukemia (AML). Proviral… Expand
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2015
2015
Classical myeloproliferative neoplasms (MPNs) are hematopoietic stem cell disorders that exhibit excess mature myeloid cells… Expand
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2015
2015
BackgroundA promising therapeutic approach for aggressive B-cell Non-Hodgkin lymphoma (NHL), including diffuse large B-cell… Expand
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Highly Cited
2014
Highly Cited
2014
Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2, and -3 promote cell proliferation… Expand
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2014
2014
ABSTRACT MET, the receptor for hepatocyte growth factor (HGF), plays an important role in signaling normal and tumor cell… Expand
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