Skip to search formSkip to main contentSkip to account menu

AZD1208

Known as: AZD 1208., AZD-1208, pan-PIM Kinase Inhibitor AZD1208 
An orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity. Pan-PIM kinase inhibitor AZD1208 inhibits the… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Biphenyl CompoundsThiazolidines
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
New mechanistic insight on the PIM-1 kinase inhibitor AZD1208 using multidrug resistant human erythroleukemia cell lines and molecular docking simulations.
PIM-1 is a kinase which has been related to the oncogenic processes like cell survival, proliferation and multidrug resistance… 
2018
2018
Targeting PIM kinase as a therapeutic strategy in human hepatoblastoma
Increasing incidence coupled with poor prognosis and treatments that are virtually unchanged over the past 20 years have made the… 
2016
2016
Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition
The PIM family of proteins encodes serine/threonine kinases with important roles in protein synthesis and cancer cell metabolism… 
2016
2016
Next-generation sequencing identifies a novel ELAVL1–TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208
Adriana E. Tron*, Erika K. Keeton*, Minwei Ye, Matias Casas-Selves, Huawei Chen, Keith S. Dillman, Rosemary E. Gale, Chloe… 
2016
2016
Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress
Internal tandem duplication of fms-like tyrosine kinase-3 (FLT3-ITD) is frequent (30 percent) in acute myeloid leukemia (AML… 
2016
2016
Combination of Pim kinase inhibitors and Bcl-2 antagonists in chronic lymphocytic leukemia cells
The Pim proteins are Ser/Thr kinases over-expressed in several hematological malignancies such as chronic lymphocytic leukemia… 
2016
2016
Constitutive activation of Pim 1 kinase is a therapeutic target for adult T-cell leukemia
• Epigenetic silencing of miR124a leads to constitutive STAT3 and activation of downstream Pim1. • Pim1 kinase signaling is… 
2015
2015
Abstract 5332: The Pim kinase inhibitor AZD1208 sensitizes acute myeloid leukemia cells with fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) to cytotoxic effects of chemotherapy…
Purpose: Internal tandem duplication (ITD) in the juxtamembrane domain of the fms-like tyrosine kinase 3 (FLT3) receptor is… 
2014
2014
Preclinical and Clinical Pharmacodynamics of Pan-Pim Inhibition By AZD1208 in Acute Myeloid Leukemia: Assessment of Pim Isoform Dependency for Bad and 4EBP1 Phosphorylation
Pim kinases have been shown to play a key role as downstream effectors of growth factor signaling in hematological malignancies… 
2011
2011
AZD1208, a Novel, Potent and Selective Pan PIM Kinase Inhibitor, Demonstrates Efficacy in Models of Acute Myeloid Leukemia
Abstract 1540 The PIM serine/threonine kinase family is composed of three highly homologous members; PIM1, PIM2 and PIM3… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)