ATR-ATRIP complex

Known as: ATR-ATRIP complex location 
A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is… (More)
National Institutes of Health

Papers overview

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2016
2016
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.
The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase checkpoint pathway maintains genome integrity; however, the role… (More)
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2016
2016
The SUMO-specific protease SENP5 controls DNA damage response and promotes tumorigenesis in hepatocellular carcinoma.
OBJECTIVE SUMOylation plays critical roles in a variety of physiological and pathological processes including tumorigenesis… (More)
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Highly Cited
2011
Highly Cited
2011
ATR autophosphorylation as a molecular switch for checkpoint activation.
The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase is a master checkpoint regulator safeguarding the genome. Upon… (More)
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Highly Cited
2010
Highly Cited
2010
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.
ATR kinase is a critical upstream regulator of the checkpoint response to various forms of DNA damage. Previous studies have… (More)
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2009
2009
The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM.
The activation of ATR-ATRIP in response to double-stranded DNA breaks (DSBs) depends upon ATM in human cells and Xenopus egg… (More)
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Highly Cited
2006
Highly Cited
2006
TopBP1 Activates the ATR-ATRIP Complex
ATR is a key regulator of checkpoint responses to incompletely replicated and damaged DNA, but the mechanisms underlying control… (More)
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Highly Cited
2005
Highly Cited
2005
Coupling of human circadian and cell cycles by the timeless protein.
The Timeless protein is essential for circadian rhythm in Drosophila. The Timeless orthologue in mice is essential for viability… (More)
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Highly Cited
2004
Highly Cited
2004
Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.
Claspin is necessary for the ATR-dependent activation of Chk1 in Xenopus egg extracts containing incompletely replicated DNA. ATR… (More)
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2004
2004
A novel protein activity mediates DNA binding of an ATR-ATRIP complex.
The function of the ATR (ataxia-telangiectasia mutated and Rad3-related)-ATRIP (ATR-interacting protein) protein kinase complex… (More)
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Highly Cited
2003
Highly Cited
2003
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
The function of the ATR (ataxia-telangiectasia mutated- and Rad3-related)-ATRIP (ATR-interacting protein) protein kinase complex… (More)
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