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ATP13A2 gene

Known as: ATP13A2, CLN12, ATPase, TYPE 13A2 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Genes
KUFOR-RAKEB SYNDROME

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
ATP13A2/PARK9 regulates endo‐/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2‐mediated scaffolding function
&NA; ATP13A2 (also called PARK9), is a transmembrane endo‐/lysosomal‐associated P5 type transport ATPase. Loss‐of‐function… 
Highly Cited
2016
Highly Cited
2016
The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
Forms of Parkinson's disease (PD) are associated with lysosomal and autophagic dysfunction. ATP13A2, which is mutated in some… 
2016
2016
Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease
We previously reported that pharmacological inhibition of a class of enzymes known as prolyl hydroxylase domain proteins (PHDs… 
2016
2016
Atp13a2 Deficiency Aggravates Astrocyte‐Mediated Neuroinflammation via NLRP3 Inflammasome Activation
Atp13a2 (Park9) gene encodes a transmembrane lysosomal P5‐type ATPase (ATP13A2), and its missense or truncation mutations leads… 
Review
2015
Review
2015
The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms
The importance of ATP13A2 (PARK9) in Parkinson's disease (PD) has emerged with the discovery that mutations in this gene cause… 
Highly Cited
2015
Highly Cited
2015
α-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2
Accumulating evidence from genetic and biochemical studies implicates dysfunction of the autophagic-lysosomal pathway as a key… 
Highly Cited
2014
Highly Cited
2014
ATP13A2/PARK9 Regulates Secretion of Exosomes and α-Synuclein
Kufor–Rakeb syndrome (KRS) is caused by loss-of-function mutations in ATP13A2 (PARK9) and characterized by juvenile-onset… 
Highly Cited
2012
Highly Cited
2012
Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.
Lysosomes are responsible for degradation and recycling of bulky cell material, including accumulated misfolded proteins and… 
Highly Cited
2011
Highly Cited
2011
Regulation of Intracellular Manganese Homeostasis by Kufor-Rakeb Syndrome-associated ATP13A2 Protein*
Mutations in the ATP13A2 gene are associated with Kufor-Rakeb syndrome (KRS) and are found also in patients with various other… 
Highly Cited
2011
Highly Cited
2011
A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in Tibetan terriers
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