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ATP13A2 gene

Known as: ATP13A2, CLN12, ATPase, TYPE 13A2 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Genes
KUFOR-RAKEB SYNDROME

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The Parkinson-associated human P5B-ATPase ATP13A2 modifies lipid homeostasis.
2018
2018
Partial loss of ATP13A2 causes selective gliosis independent of robust lipofuscinosis
Highly Cited
2016
Highly Cited
2016
Atp13a2 Deficiency Aggravates Astrocyte‐Mediated Neuroinflammation via NLRP3 Inflammasome Activation
Atp13a2 (Park9) gene encodes a transmembrane lysosomal P5‐type ATPase (ATP13A2), and its missense or truncation mutations leads… 
Highly Cited
2015
Highly Cited
2015
α-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2
Accumulating evidence from genetic and biochemical studies implicates dysfunction of the autophagic-lysosomal pathway as a key… 
2015
2015
α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9)
2014
2014
Identification of p.Gln858* in ATP13A2 in two EOPD patients and presentation of their clinical features
2014
2014
ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter α-Synuclein Metabolism in SH-SY5Y Cells
Parkinson's disease is a multifactorial disorder with several genes linked to the familial types of the disease. ATP13A2 is one… 
Review
2014
Review
2014
Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases
Understanding the molecular pathogenesis of Parkinson's disease (PD) is a priority area in biomedical research. It is a pre… 
Highly Cited
2012
Highly Cited
2012
Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.
Lysosomes are responsible for degradation and recycling of bulky cell material, including accumulated misfolded proteins and… 
Highly Cited
2011
Highly Cited
2011
Regulation of Intracellular Manganese Homeostasis by Kufor-Rakeb Syndrome-associated ATP13A2 Protein*
Mutations in the ATP13A2 gene are associated with Kufor-Rakeb syndrome (KRS) and are found also in patients with various other… 
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