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ATP13A2 gene
Known as:
ATP13A2
, CLN12
, ATPase, TYPE 13A2
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National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Genes
KUFOR-RAKEB SYNDROME
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
ATP13A2/PARK9 regulates endo‐/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2‐mediated scaffolding function
Ş. Demirsoy
,
S. Martin
,
+7 authors
P. Agostinis
Human molecular genetics
2017
Corpus ID: 40748978
&NA; ATP13A2 (also called PARK9), is a transmembrane endo‐/lysosomal‐associated P5 type transport ATPase. Loss‐of‐function…
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Highly Cited
2016
Highly Cited
2016
The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway
C. Bento
,
A. Ashkenazi
,
M. Jimenez-Sanchez
,
D. Rubinsztein
Nature communications
2016
Corpus ID: 19431902
Forms of Parkinson's disease (PD) are associated with lysosomal and autophagic dysfunction. ATP13A2, which is mutated in some…
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2016
2016
Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease
Subramanian Rajagopalan
,
A. Rane
,
S. Chinta
,
J. Andersen
The Journal of Neuroscience
2016
Corpus ID: 10211382
We previously reported that pharmacological inhibition of a class of enzymes known as prolyl hydroxylase domain proteins (PHDs…
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2016
2016
Atp13a2 Deficiency Aggravates Astrocyte‐Mediated Neuroinflammation via NLRP3 Inflammasome Activation
Chen Qiao
,
Nuo Yin
,
+4 authors
G. Hu
CNS neuroscience & therapeutics
2016
Corpus ID: 205016122
Atp13a2 (Park9) gene encodes a transmembrane lysosomal P5‐type ATPase (ATP13A2), and its missense or truncation mutations leads…
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Review
2015
Review
2015
The role of ATP13A2 in Parkinson's disease: Clinical phenotypes and molecular mechanisms
Jin-Sung Park
,
N. Blair
,
C. Sue
Movement disorders : official journal of the…
2015
Corpus ID: 1364445
The importance of ATP13A2 (PARK9) in Parkinson's disease (PD) has emerged with the discovery that mutations in this gene cause…
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Highly Cited
2015
Highly Cited
2015
α-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2
Lauren R. Kett
,
Barbara Stiller
,
+9 authors
W. Dauer
The Journal of Neuroscience
2015
Corpus ID: 12982260
Accumulating evidence from genetic and biochemical studies implicates dysfunction of the autophagic-lysosomal pathway as a key…
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Highly Cited
2014
Highly Cited
2014
ATP13A2/PARK9 Regulates Secretion of Exosomes and α-Synuclein
T. Tsunemi
,
Kana Hamada
,
D. Krainc
The Journal of Neuroscience
2014
Corpus ID: 34965713
Kufor–Rakeb syndrome (KRS) is caused by loss-of-function mutations in ATP13A2 (PARK9) and characterized by juvenile-onset…
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Highly Cited
2012
Highly Cited
2012
Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.
M. Usenovic
,
A. L. Knight
,
+6 authors
D. Krainc
Human molecular genetics
2012
Corpus ID: 6472526
Lysosomes are responsible for degradation and recycling of bulky cell material, including accumulated misfolded proteins and…
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Highly Cited
2011
Highly Cited
2011
Regulation of Intracellular Manganese Homeostasis by Kufor-Rakeb Syndrome-associated ATP13A2 Protein*
Jieqiong Tan
,
Tongmei Zhang
,
+5 authors
Zhuohua Zhang
The Journal of Biological Chemistry
2011
Corpus ID: 6003708
Mutations in the ATP13A2 gene are associated with Kufor-Rakeb syndrome (KRS) and are found also in patients with various other…
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Highly Cited
2011
Highly Cited
2011
A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in Tibetan terriers
F. H. Farias
,
R. Zeng
,
+11 authors
M. Katz
Neurobiology of Disease
2011
Corpus ID: 38204576
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