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ATI-5261

National Institutes of Health

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Peptides

Papers overview

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2018
2018
Apolipoprotein A1 mimetic peptide ATI-5261 reverses arterial stiffness at late pregnancy and early postpartum in a COMT−/− mouse model of preeclampsia
BackgroundPreeclampsia (PE) is a serious maternal complication during pregnancy. Associated arterial stiffness in PE patients… 
2014
2014
Abstract 626: The ABCA1 Agonist Peptides CS-6253 and ATI-5261 Replicate ApoA-I Function and Generate nHDL Particles that Are Remodeled and Maturated Within the Plasma Compartment, Resulting in…
Novel apolipoprotein (apo) mimetic peptides are potent mediators of ABCA1-mediated cholesterol efflux, mimicking native apoA-I… 
2013
2013
Abstract 402: HDL Mimetic Peptides ATI-5261 and CS-6253 Induce ABCA1 Oligomerization, Cellular Cholesterol Efflux and Generate Nascent HDL-Like Lipoproteins
Novel approaches that target HDL biogenesis may increase nascent HDL-like particle formation that can be used for therapeutic… 
2013
2013
Abstract 13853: Biological Action of ABCA1 Ligand Peptide ATI-5261 and its Analogs With Improved Safety Features
Recent studies have produced apolipoprotein (apo) mimetic peptides that reduce substantial atherosclerosis in animal models when… 
2013
2013
Abstract 14760: Apolipoprotein (apo) Mimetic Peptides ATI-5261 and CS-6253 Induce ABCA1/ABCG1 Mediated HDL Formation and Maturation in a Process Including ABCA1 Oligomerization and LCAT in Way…
Two novel (26-AA) apolipoprotein (apo) mimetic peptides ATI-5261 and CS-6253 were studied in vitro for their ability to interact… 
2012
2012
The positional specificity of EXXK motifs within an amphipathic α-helix dictates preferential lysine modification by acrolein: implications for the design of high-density lipoprotein mimetic peptides…
Despite the ability of acrolein to damage proteins, factors governing its reactivity with the ε-amino group of lysine are poorly… 
2011
2011
HDL mimetic peptide ATI-5261 forms an oligomeric assembly in solution that dissociates to monomers upon dilution.
ATI-5261 is a 26-mer peptide that stimulates cellular cholesterol efflux with high potency. This peptide displays high aqueous… 
Highly Cited
2010
Highly Cited
2010
A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice
Here, we report the creation of a single-helix peptide (ATI-5261) that stimulates cellular cholesterol efflux with Km molar… 
2009
2009
Abstract 1093: The Novel Apolipoprotein Mimetic Peptide ATI-5261 Induces Pre{beta}-1 HDL Formation in Human Plasma via a Highly Specific Mechanism Involving Distinct {alpha}-HDL Subpopulations
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