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ATF4 gene

Known as: ACTIVATING TRANSCRIPTION FACTOR 4, TAX-RESPONSIVE ENHANCER ELEMENT B67, Activating Transcription Factor 4 Gene 
This gene plays a role in transcription.
National Institutes of Health

Related topics

Related topics

6 relations
ATF2 geneATF2 protein, humanATF4 protein, humanActivating Transcription Factor 4

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ATF2 wt Allele

Papers overview

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Highly Cited
2012
Highly Cited
2012
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy.
Mutations leading to expansion of a poly-glutamine track in Huntingtin (Htt) cause Huntington's disease (HD). Signs of… 
Highly Cited
2011
Highly Cited
2011
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
Loss of parkin function is responsible for the majority of autosomal recessive parkinsonism. Here, we show that parkin is not… 
Highly Cited
2009
Highly Cited
2009
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells
The ubiquitin-proteasome system has recently emerged as a major target for drug development in cancer therapy. The proteasome… 
Highly Cited
2009
Highly Cited
2009
The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib.
The ubiquitin-proteasome system plays a key regulatory role in cellular homeostasis. The inhibition of the 26S proteasome by… 
Review
2008
Review
2008
Activating transcription factor 4.
Highly Cited
2007
Highly Cited
2007
TRB3 Inhibits the Transcriptional Activation of Stress-regulated Genes by a Negative Feedback on the ATF4 Pathway*
The integrated stress response (ISR) is defined as a highly conserved response to several stresses that converge to the induction… 
Highly Cited
2004
Highly Cited
2004
Induction of CHOP Expression by Amino Acid Limitation Requires Both ATF4 Expression and ATF2 Phosphorylation*
The CHOP gene is transcriptionally induced by amino acid starvation. We have previously identified a genomic cis-acting element… 
Highly Cited
2003
Highly Cited
2003
Inducible Enhancement of Memory Storage and Synaptic Plasticity in Transgenic Mice Expressing an Inhibitor of ATF4 (CREB-2) and C/EBP Proteins
Highly Cited
2001
Highly Cited
2001
Identification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein
Nrf2 regulates expression of genes encoding enzymes with antioxidant (e.g. heme oxygenase-1 (HO-1)) or xenobiotic detoxification… 
Highly Cited
2001
Highly Cited
2001
ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCFβTrCPUbiquitin Ligase
ABSTRACT The ubiquitin-proteasome pathway regulates gene expression through protein degradation. Here we show that the F-box… 
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