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AT7519

Known as: AT 7519, AT-7519, AT7519M 
 
National Institutes of Health

Papers overview

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2015
2015
Purpose: MYCN-dependent neuroblastomas have low cure rates with current multimodal treatment regimens and novel therapeutic drugs… Expand
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2015
2015
AbstractPurpose ATP-binding cassette (ABC) transporters play an important role in multidrug resistance (MDR) toward anticancer… Expand
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Highly Cited
2014
Highly Cited
2014
A vast number of small-molecule ligands, including therapeutic drugs under development and in clinical use, elicit their effects… Expand
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2014
2014
Background:AT7519 is a small-molecular inhibitor of multiple cyclin-dependent kinases (CDKs). It shows encouraging anti-cancer… Expand
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2011
2011
Background Eosinophils not only defend the body against parasitic infection but are also involved in pathological inflammatory… Expand
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Highly Cited
2010
Highly Cited
2010
Dysregulated cell cycling is a universal hallmark of cancer and is often mediated by abnormal activation of cyclin-dependent… Expand
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2010
2010
AT7519 is a potent inhibitor of several cyclin-dependent kinases and is currently in early phase clinical development. Recently… Expand
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Highly Cited
2009
Highly Cited
2009
Cyclin-dependent kinases (CDK), and their regulatory cyclin partners, play a central role in eukaryotic cell growth, division… Expand
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Highly Cited
2008
Highly Cited
2008
The application of fragment-based screening techniques to cyclin dependent kinase 2 (CDK2) identified multiple (>30) efficient… Expand
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2008
2008
Cyclin dependent kinases (CDKs) and their cyclin complexes play a crucial role in cell cycle control and transcriptional… Expand