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AT 406

Known as: AT406 cpd, IAP Inhibitor AT-406, Pyrrolo(1,2-a)(1,5)diazocine-8-carboxamide, n-((1,1'-biphenyl)-2-ylmethyl)decahydro-5-(((2s)-2-(methylamino)-1-oxopropyl)amino)-3-(3-methyl-1-oxobutyl)-6-oxo-, (5s,8s,10ar) 
An orally bioavailable inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins with potential apoptotic inducing and antineoplastic… 
National Institutes of Health

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2 relations
NCIt Antineoplastic Agent TerminologySM 406

Papers overview

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2016
2016
IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis
High expression levels of Inhibitors of Apoptosis Proteins (IAPs) have been correlated with poor cancer prognosis and block the… 
2016
2016
Acquired cisplatin resistance in malignant pleural mesothelioma cells is reversed by both BH3-mimetic obatoclax and IAP-inhibitor AT-406
Background Cisplatin is used for treatment of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) but… 
2014
2014
Abstract 2757: Pharmaco imaging study of the effects of Debio 1143, a new orally available IAP inhibitor, in a triple negative breast cancer model
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Introduction: Inhibitors of apoptosis proteins (IAPs) are… 
2009
2009
Abstract #1917: Synergistic effect of AT-406, a small molecule inhibitor of XIAP, with chemotherapy and tyrosine kinase inhibitors
X-linked inhibitor of apoptosis protein (XIAP) suppresses apoptosis in cells by inhibiting the apoptosis caspase-9 and caspase-3… 
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