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AT 13387

Known as: AT-13387, AT13387 
 
National Institutes of Health

Papers overview

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2015
2015
Overexpression of heat shock protein 90 (HSP90) is associated with increased tumor cell survival and radioresistance. In this… Expand
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2015
2015
PurposeHeat shock protein 90 (HSP90) is essential for the activation and stabilization of numerous oncogenic client proteins… Expand
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2015
2015
SummaryInhibition of heat shock 90 (Hsp90) molecular chaperones allows targeting of multiple proteins involved in tumorigenesis… Expand
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2014
2014
Emergence of clinical resistance to BRAF inhibitors, alone or in combination with MEK inhibitors, limits clinical responses in… Expand
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2013
2013
BackgroundNasopharyngeal carcinoma (NPC) is an epithelial malignancy strongly associated with Epstein-Barr virus (EBV). AT13387… Expand
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2012
2012
The epidermal growth factor receptor (EGFR) has been targeted for inhibition using tyrosine kinase inhibitors and monoclonal… Expand
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2012
2012
The majority of gastrointestinal stromal tumors (GIST) are characterized by activating mutations of KIT, an HSP90 client protein… Expand
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2012
2012
A ubiquitously expressed chaperone, heat shock protein 90 (HSP90) is of considerable interest as an oncology target because tumor… Expand
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2011
2011
Hsp90 is involved in correcting, folding, maturation and activation of a diverse array of client proteins; it has also been… Expand
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Highly Cited
2010
Highly Cited
2010
Inhibitors of the molecular chaperone heat shock protein 90 (Hsp90) are currently generating significant interest in clinical… Expand
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