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ARC 1779

Known as: ARC-1779, ARC1779 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Aptamers, Nucleotide
ULvWF Multimer-targeting Agent ARC1779

Papers overview

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2012
2012
Initial experience from a double-blind, placebo-controlled, clinical outcome study of ARC1779 in patients with thrombotic thrombocytopenic purpura.
 
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2012
2012
The anti-von Willebrand factor aptamer ARC1779 increases von Willebrand factor levels and platelet counts in patients with type 2B von Willebrand disease.
Blockade of hyperactive von Willebrand factor (VWF) by ARC1779 blunted the platelet drop induced by desmopressin in patients with… Expand
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2011
2011
Inhibition of von Willebrand factor by ARC1779 in patients with acute thrombotic thrombocytopenic purpura.
Thrombotic thrombocytopenic purpura (TTP) can cause severe organ damage due to enhanced platelet aggregation by ultra-large von… Expand
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Review
2010
Review
2010
Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases.
Platelet inhibitors are the mainstay treatment for patients with vascular diseases. The current 'gold standard' antiplatelet… Expand
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2010
2010
A randomised pilot trial of the anti-von Willebrand factor aptamer ARC1779 in patients with type 2b von Willebrand disease.
Desmopressin aggravates thrombocytopenia in type 2B von Willebrand disease (VWF type 2B) by release of large and hyper-adhesive… Expand
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2010
2010
The aptamer ARC1779 blocks von Willebrand factor-dependent platelet function in patients with thrombotic thrombocytopenic purpura ex vivo.
BACKGROUND In thrombotic thrombocytopenic purpura (TTP), ultralarge von Willebrand factor (VWF) multimers bind platelet (PLT… Expand
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2009
2009
Anti-von Willebrand factor aptamer ARC1779 for refractory thrombotic thrombocytopenic purpura.
BACKGROUND Plasma exchange is the main therapy for thrombotic thrombocytopenic purpura (TTP). No treatments other than plasma… Expand
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2009
2009
The aptamer ARC1779 is a potent and specific inhibitor of von willebrand factor mediated ex vivo platelet function in acute myocardial infarction
ARC1779 is an aptamer, which blocks binding of the von Willebrand Factor (VWF) A1 domain to platelet GPIb receptors. VWF is… Expand
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2007
2007
First-inHuman Evaluation of Anti – von Willebrand Factor Therapeutic Aptamer ARC 1779 in Healthy Volunteers
Background—ARC1779 is a therapeutic aptamer antagonist of the A1 domain of von Willebrand Factor (vWF), the ligand for receptor… Expand
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Highly Cited
2007
Highly Cited
2007
First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers.
BACKGROUND ARC1779 is a therapeutic aptamer antagonist of the A1 domain of von Willebrand Factor (vWF), the ligand for receptor… Expand
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