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AR C69931MX

Known as: AR-C69931MX 
National Institutes of Health

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1 relation

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cangrelor

Papers overview

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Highly Cited
2008
Highly Cited
2008
P2Y12 Receptors in Spinal Microglia Are Required for Neuropathic Pain after Peripheral Nerve Injury
Extracellular nucleotides have been implicated as signaling molecules used by microglia to sense adverse physiological conditions… 
Highly Cited
2008
Highly Cited
2008
Akt activation is involved in P2Y12 receptor‐mediated chemotaxis of microglia
Microglia play a variety of significant roles in the central nervous system (CNS), and in one of those roles they undergo… 
Highly Cited
2007
Highly Cited
2007
Glycoprotein Ibα inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques
Summary Anti-platelet drugs are used to prevent intra-arterial thrombus formation after rupture of atherosclerotic plaques. Until… 
Highly Cited
2006
Highly Cited
2006
P2Y12 receptor‐mediated potentiation of thrombin‐induced thromboxane A2 generation in platelets occurs through regulation of Erk1/2 activation
Summary.  Background: Thromboxane A2 (TXA2) is a positive feedback lipid mediator that is generated upon stimulation of platelets… 
Highly Cited
2004
Highly Cited
2004
Costimulation of the Gi‐coupled ADP receptor and the Gq‐coupled TXA2 receptor is required for ERK2 activation in collagen‐induced platelet aggregation
Highly Cited
2002
Highly Cited
2002
Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and AR-C69931MX in patients with ischaemic heart disease
We compared the antiplatelet effects of clopidogrel and the intravenous platelet P2Y 12 receptor antagonist AR-C69931MX, which… 
Highly Cited
2002
Highly Cited
2002
Inhibition of ADP-induced P-selectin Expression and Platelet-Leukocyte Conjugate Formation by Clopidogrel and the P2Y12 Receptor Antagonist AR-C69931MX but not Aspirin
Summary Platelet-leukocyte interactions are recognised to have pro-inflammatory effects, which may be important in the… 
Highly Cited
2001
Highly Cited
2001
Open Multicentre Study of the P 2T Receptor Antagonist AR-C69931MX Assessing Safety, Tolerability and Activity in Patients with Acute Coronary Syndromes
Summary Platelet aggregation is the central process in the pathophysiology of acute coronary syndromes. ADP contributes to… 
Highly Cited
2000
Highly Cited
2000
Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model.
P2Y1, P2X1, and P2T receptors mediate ADP-induced platelet aggregation. The antithrombotic effects of AR-C69931MX (N6-[2… 
Highly Cited
1999
Highly Cited
1999
Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy.
The platelet P2T receptor plays a major role in platelet aggregation, and its antagonists are predicted to have significant… 
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