Skip to search formSkip to main contentSkip to account menu

AQ4N

Known as: 1,4-bis-((2-(dimethylamino-N-oxide)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione, 9,10-Anthracenedione, 1,4-bis((2-(dimethylamino)ethyl)amino)-5,8-dihydroxy-, N,N'-dioxide, BANOXANTRONE 
A bioreductive, alkylaminoanthraquinone prodrug with antineoplastic activity. Under hypoxic conditions, often seen in solid tumors, banoxantrone… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Photodynamic therapy (PDT), a noninvasive cancer therapeutic method triggered by light, would lead to severe tumor hypoxia after… 
Highly Cited
2010
Highly Cited
2010
AQ4N [1,4-bis{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione], a prodrug with two dimethylamino N… 
Highly Cited
2008
Highly Cited
2008
Purpose: AQ4N is a novel bioreductive prodrug under clinical investigation. Preclinical evidence shows that AQ4N penetrates… 
Review
2008
Review
2008
Review
2007
Review
2007
  • P. Wardman
  • Clinical oncology (Royal College of Radiologists…
  • 2007
  • Corpus ID: 34738474
Review
2007
Review
2007
Review
2004
Review
2004
The concept of overexpression of individual forms of cytochrome P450 enzymes in tumor cells is now becoming well recognized… 
Review
2002
Review
2002
Aliphatic amine N-oxides have long been identified as non-toxic metabolites of a large number of tertiary amines drugs… 
Highly Cited
1995
Highly Cited
1995
AQ4N (1,4-bis([2-(dimethylamino-N-oxide)ethyl]amino)5,8-dihydroxy- anthracene-9,10-dione) is a novel alkylaminoanthraquinone N…