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AQ4N

Known as: 1,4-bis-((2-(dimethylamino-N-oxide)ethyl)amino)-5,8-dihydroxyanthracene-9,10-dione, 9,10-Anthracenedione, 1,4-bis((2-(dimethylamino)ethyl)amino)-5,8-dihydroxy-, N,N'-dioxide, BANOXANTRONE 
A bioreductive, alkylaminoanthraquinone prodrug with antineoplastic activity. Under hypoxic conditions, often seen in solid tumors, banoxantrone… Expand
National Institutes of Health

Papers overview

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2010
2010
AQ4N [1,4-bis{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione], a prodrug with two dimethylamino N… Expand
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2009
2009
Hypoxic tumor cells are likely to be resistant to conventional chemotherapy, in large part because many anticancer drugs are… Expand
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Highly Cited
2008
Highly Cited
2008
PURPOSE AQ4N is a novel bioreductive prodrug under clinical investigation. Preclinical evidence shows that AQ4N penetrates deeply… Expand
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Review
2007
Review
2007
  • Peter Wardman
  • Clinical oncology (Royal College of Radiologists…
  • 2007
  • Corpus ID: 34738474
Radiosensitizers are intended to enhance tumour cell killing while having much less effect on normal tissues. Some drugs target… Expand
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2007
2007
AQ4N (banoxatrone) (1,4-bis-{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione) is an example of a… Expand
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Review
2002
Review
2002
Aliphatic amine N-oxides have long been identified as non-toxic metabolites of a large number of tertiary amines drugs… Expand
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Review
2002
Review
2002
The expression of drug metabolising cytochrome P450s (CYPs) notably 1A, 1B, 2C, 3A, 2D subfamily members have been identified in… Expand
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Review
2000
Review
2000
Preclinical studies demonstrate that in vivo AQ4N enhances the anti-tumour effects of radiation and chemotherapeutic agents with… Expand
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1998
1998
PURPOSE To establish the role of the human cytochromes P450 (CYPs) in the reductive metabolism of the novel anthraquinone di-N… Expand
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1995
1995
AQ4N (1,4-bis([2-(dimethylamino-N-oxide)ethyl]amino)5,8-dihydroxy- anthracene-9,10-dione) is a novel alkylaminoanthraquinone N… Expand
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