APR-246
National Institutes of Health
Papers overview
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Východiska : Nejcastěji mutovaným proteinem u nadorových onemocněni je p53 a jednou z možnosti protinadorove terapie je…
The p53 gene family consists of p53, p63 and p73. The three proteins share a high degree of structural similarity in their DNA…
Targeting p53 by the small-molecule PRIMA-1/APR-246 has shown promising preclinical activity in various cancer types. However…
Purpose: Small cell lung cancer (SCLC) is a highly malignant disease with poor prognosis, necessitating the need to develop new…