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APR-246

 
National Institutes of Health

Papers overview

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2018
2018
Introduction: TP53 mutant (mTP53) MDS and AML, accounting for 5-10% of de novo MDS and 25-30% of therapy related MDS (t-MDS… Expand
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Review
2017
Review
2017
TP53 (p53) is the single most frequently altered gene in human cancers, with mutations being present in approximately 50% of all… Expand
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Highly Cited
2017
Highly Cited
2017
TP53, a critical tumour suppressor gene, is mutated in over half of all cancers resulting in mutant-p53 protein accumulation and… Expand
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Review
2016
Review
2016
TP53 is the most frequently mutated gene in cancer. The p53 protein activates transcription of genes that promote cell cycle… Expand
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2016
2016
Intrinsic and acquired resistance of metastatic melanoma to (V600E/K)BRAF and/or MEK inhibitors, which is often caused by… Expand
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2016
2016
Mutations in the TP53 tumor suppressor gene occur at different frequencies in a variety of human malignancies. TP53 encodes a DNA… Expand
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2015
2015
OBJECTIVES p53 is a critical tumour suppressor and is mutated in 70% of oesophageal adenocarcinomas (OACs), resulting in… Expand
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Review
2014
Review
2014
The TP53 tumor suppressor gene is mutated in many human tumors, including common types of cancer such as colon and ovarian cancer… Expand
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2011
2011
BACKGROUND APR-246 belongs to a new generation of the compounds that restore normal p53 function in cells with mutated or wild… Expand
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Review
2010
Review
2010
The p53 tumor suppressor pathway blocks tumor development by triggering apoptosis or cellular senescence in response to oncogenic… Expand
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