APH1B gene

Known as: APH1B, aph-1 homolog B, gamma secretase subunit, DKFZp564D0372 
 
National Institutes of Health

Papers overview

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2014
2014
Neuregulin 1 (NRG1) and the γ-secretase subunit APH1B have been previously implicated as genetic risk factors for schizophrenia… (More)
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2009
2009
Gamma-secretase is a unique intramembrane-cleaving protease complex, which cleaves the Alzheimer's disease-associated beta… (More)
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2009
2009
The sodium-bicarbonate cotransporter NBC1 is targeted exclusively at the basolateral membrane. Mutagenesis of a dihydrophobic FL… (More)
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2008
2008
Gamma-secretase is an intramembrane cleaving aspartyl protease complex intimately implicated in Alzheimer disease pathogenesis… (More)
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2006
2006
APH-1 is one of the four essential components of presenilin (PS)-γ-secretase complexes. There are three major isoforms of APH-1… (More)
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2005
2005
A combination of genetic factors and early life events is thought to determine the vulnerability of an individual to develop a… (More)
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2005
2005
APH-1 is one of the four essential components of the presenilin-gamma-secretase complex and has two human homologs, APH-1a, and… (More)
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Highly Cited
2004
Highly Cited
2004
Gamma-secretase is a member of a new class of proteases with an intramembrane catalytic site and cleaves numerous type I membrane… (More)
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Highly Cited
2004
Highly Cited
2004
The gamma-secretase complex catalyzes the final intramembraneous cleavage of the beta-amyloid precursor protein, liberating the… (More)
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2003
2003
Recent biological studies indicate the importance of anterior-pharynx defective-1 (APH-1) proteins in Alzheimer's disease (AD… (More)
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