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APH1B gene

Known as: APH1B, aph-1 homolog B, gamma secretase subunit, DKFZp564D0372 
National Institutes of Health

Papers overview

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2012
2012
Different types of γ-secretes complexes and their effect on substrate processing
The γ-secretase complex is a transmembrane aspartyl protease that generates the Alzheimer disease (AD) related amyloid β-peptide… 
2010
2010
A multi-factor integrated fault diagnosis method for distributed applications
Fault management is a key research part in the field of distributed applications management. Fault Management based on active… 
2009
2009
Sequence- or Position-Specific Mutations in the Carboxyl-Terminal FL Motif of the Kidney Sodium Bicarbonate Cotransporter (NBC1) Disrupt Its Basolateral Targeting and α-Helical Structure
The sodium-bicarbonate cotransporter NBC1 is targeted exclusively at the basolateral membrane. Mutagenesis of a dihydrophobic FL… 
2008
2008
Chemical Cross-linking Provides a Model of the γ-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1*
γ-Secretase is an intramembrane cleaving aspartyl protease complex intimately implicated in Alzheimer disease pathogenesis. The… 
2008
2008
Interaction between the APOE epsilon4 allele and the APH-1b c + 651T > G SNP in Alzheimer's disease.
The gamma-secretase complex is a multimeric aspartyl protease which plays a pivotal role in the production of amyloid beta… 
2007
2007
Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif
APH-1 is one of the four essential components of presenilin (PS)-γ-secretase complexes. There are three major isoforms of APH-1… 
2005
2005
Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes.
2005
2005
Identification and characterization of a novel human APH-1b splice variant lacking exon 4.
2003
2003
Association analysis between anterior-pharynx defective-1 genes polymorphisms and Alzheimer's disease
1995
1995
Cloning and Sequencing of Chickpea cDNA Coding for Threonine Deaminase
TD (EC 4.2.1.16) is the enzyme catalyzing the conversion of L-Thr to a-ketobutyrate, the first step of the pathway leading to the… 
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