AP23464
National Institutes of Health
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Chronic myeloid leukemia (CML) was the first human malignant disease to be linked to a single, acquired genetic abnormality…
The tyrosine kinase pp60src (Src) is the prototypical member of a family of proteins that participate in a broad array of…
Imatinib mesylate, Abl tyrosine kinase inhibitor, has improved the treatment of Bcr-Abl-positive leukemia such as chronic myeloid…
Oncogenic mutations of the Kit receptor tyrosine kinase occur in several types of malignancy. Juxtamembrane domain mutations are…
Oncogenic mutations of the KIT receptor tyrosine kinase have been identified in several malignancies including gastrointestinal…