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Several new targeted genes and clinical subtypes have been identified since publication in 2008 of the report of the… Expand Background Nail lichen planus affects 10% of all patients with lichen planus. It is a severe disease that may lead to… Expand The four vertebrate R-spondin proteins are secreted agonists of the canonical Wnt/β-catenin signaling pathway. These proteins are… Expand
Duplications of noncoding elements 5′ of SOX9 are associated with brachydactyly-anonychia
Recently, we reported that mutations in the R-spondin 4 (RSPO4) gene underlie inherited anonychia/hyponychia. Here, we studied… Expand Anonychia and hyponychia congenita (OMIM 206800) are rare autosomal recessive conditions in which the only presenting phenotype… Expand Anonychia is an autosomal recessive disorder characterized by the congenital absence of finger- and toenails. In a large German… Expand Guttmacher syndrome, a dominantly inherited combination of distal limb and genital tract abnormalities, has several features in… Expand
The possible teratogenic effects of prostaglandins (PGs) in humans have not been investigated in detail, yet these drugs appear… Expand In the hope of identifying an allele of the gene which causes the nail, elbow, patellar and ‘iliac horn’ anomalies of the nail… Expand