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AMG531

Known as: AMG 531, Amgen Megakaryopoiesis protein 531 
A recombinant protein with megakarypoiesis stimulating activity. AMG 531 mimics endogenous thrombopoietin (TPO), directly binding to and activating… 
National Institutes of Health

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Broader (1)

romiplostim

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
AMG 531, a Thrombopoiesis-Stimulating Protein, for Chronic ITP
Review
2008
Review
2008
New drugs for familiar therapeutic targets: thrombopoietin receptor agonists and immune thrombocytopenic purpura
Various agents to treat immune thrombocytopenic purpura (ITP) have been developed on the principle that stimulating the… 
Review
2007
Review
2007
Review article: pharmacological approaches for the treatment of thrombocytopenia in patients with chronic liver disease and hepatitis C infection
Background  Patients with chronic liver disease and hepatitis C virus (HCV) frequently experience thrombocytopenia that… 
2007
2007
Evaluation of AMG 531 Safety in Splenectomized (S) and Nonsplenectomized (NS) Patients with Chronic Immune Thrombocytopenic Purpura (ITP) in Two Randomized Placebo-Controlled Phase 3 Studies
AMG 531 is a novel platelet-stimulating peptibody that stimulates the thrombopoietin (TPO) receptor, and is being studied for its… 
Review
2007
Review
2007
New therapeutic options for adult chronic immune thrombocytopenic purpura: a brief review
Background  Patients with chronic immune thrombocytopenic purpura (ITP) only require treatment if they are bleeding, or prior to… 
2007
2007
Evaluation of AMG 531 Efficacy in Splenectomized Patients with Chronic Immune Thrombocytopenic Purpura (ITP) in a Randomized Placebo-Controlled Phase 3 Study.
AMG 531 is a novel thrombopoiesis-stimulating peptibody that acts by stimulating the thrombopoietin (TPO) receptor. We report… 
2007
2007
Health-Related Quality of Life (HRQoL) in Patients with Chronic Immune Thrombocytopenic Purpura (ITP): Interim Results from an Open-Label Study of AMG 531.
The ITP Patient Assessment Questionnaire (ITP-PAQ) was developed to complement clinical data by assessing multiple facets of… 
2007
2007
A Comparative Proteomic Analysis of Platelets from Healthy Human Patients and Chronic ITP Patients Receiving AMG 531, a Thrombopoiesis-Stimulating Protein.
AMG 531 is a novel thrombopoiesis-stimulating “peptibody” consisting of an Fc carrier domain linked to 4 identical peptides that… 
2007
2007
AMG 531 for chronic ITP.
n engl j med 356;3 www.nejm.org january 18, 2007 307 is still unknown for carotid stenting. These findings suggest a potential… 
2005
2005
The novel thrombopoietic agent AMG 531 is effective in pre-clinical models of chemo/radiotherapy induced thrombocytopenia
1233 AMG 531 is a novel thrombopoietic agent that engages c-mpl and has been demonstrated to elevate platelet counts in normal… 
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