AMG-3969
National Institutes of Health
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A nonracemic synthesis of the glucokinase-glucokinase regulatory protein disruptor AMG-3969 (5) is reported. Key features of the…
We have recently reported a novel approach to increase cytosolic glucokinase (GK) levels through the binding of a small molecule…
In the previous report , we described the discovery and optimization of novel small molecule disruptors of the GK-GKRP…
Glucose homeostasis is a vital and complex process, and its disruption can cause hyperglycaemia and type II diabetes mellitus…