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AMG-3969

 
National Institutes of Health

Papers overview

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2014
2014
Nonracemic synthesis of GK-GKRP disruptor AMG-3969.
A nonracemic synthesis of the glucokinase-glucokinase regulatory protein disruptor AMG-3969 (5) is reported. Key features of the… Expand
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2014
2014
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine…
We have recently reported a novel approach to increase cytosolic glucokinase (GK) levels through the binding of a small molecule… Expand
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2014
2014
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
In the previous report , we described the discovery and optimization of novel small molecule disruptors of the GK-GKRP… Expand
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Highly Cited
2013
Highly Cited
2013
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors
Glucose homeostasis is a vital and complex process, and its disruption can cause hyperglycaemia and type II diabetes mellitus… Expand
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