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AMG 232

Known as: AMG-232, MDM2 Inhibitor AMG-232 
An orally available, piperidinone inhibitor of MDM2 (murine double minute 2), with potential antineoplastic activity. Upon oral administration, MDM2… Expand
National Institutes of Health

Papers overview

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2019
2019
This open-label, phase 1 study evaluated the safety, pharmacokinetics, and maximum tolerated dose of AMG 232, an investigational… Expand
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2017
2017
2575Background: Large sequencing studies in MCM have shown a TP53WT incidence of approximately 80%. In preclinical TP53WT… Expand
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Review
2016
Review
2016
Background This open-label, first-in-human, phase 1 study evaluated AMG 232, an oral selective MDM2 inhibitor in patients with… Expand
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2015
2015
p53 is a critical tumor suppressor and is the most frequently inactivated gene in human cancer. Inhibition of the interaction of… Expand
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2015
2015
1. AMG 232 is a novel inhibitor of the p53-MDM2 protein-protein interaction currently in Phase I clinical trials for multiple… Expand
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2015
2015
MDM2-p53 interaction and downstream signaling affect cellular response to DNA damage. AMG 232 is a potent small molecule… Expand
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Highly Cited
2014
Highly Cited
2014
We recently reported the discovery of AM-8553 (1), a potent and selective piperidinone inhibitor of the MDM2-p53 interaction… Expand
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2014
2014
Activation of p53 is an attractive therapeutic target in radiation oncology because of its tumor-suppressor activity. AMG 232 is… Expand
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2014
2014
The p53 tumor suppressor is controlled by MDM2, which binds p53 and negatively regulates its transcriptional activity and… Expand
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2014
2014
The p53 tumor suppressor is controlled by MDM2, which binds p53 and negatively regulates its transcriptional activity and… Expand
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