AMG 232

Known as: AMG-232, MDM2 Inhibitor AMG-232 
An orally available, piperidinone inhibitor of MDM2 (murine double minute 2), with potential antineoplastic activity. Upon oral administration, MDM2… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2014-2017
02420142017

Papers overview

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2017
2017
Purpose: Adenoid cystic carcinoma (ACC) is a rare cancer arising from the major or minor salivary gland tissues of the head and… (More)
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2015
2015
p53 is a critical tumor suppressor and is the most frequently inactivated gene in human cancer. Inhibition of the interaction of… (More)
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2015
2015
1. AMG 232 is a novel inhibitor of the p53-MDM2 protein-protein interaction currently in Phase I clinical trials for multiple… (More)
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2015
2015
MDM2-p53 interaction and downstream signaling affect cellular response to DNA damage. AMG 232 is a potent small molecule… (More)
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2015
2015
MDM2–p53 interaction and downstream signaling affect cellular response to DNA damage. AMG 232 is a potent small molecule… (More)
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2014
2014
We recently reported the discovery of AM-8553 (1), a potent and selective piperidinone inhibitor of the MDM2-p53 interaction… (More)
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2014
2014
We recently reported on the discovery of AMG 232, a potent and selective piperidinone inhibitor of the MDM2-p53 interaction. AMG… (More)
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Review
2014
Review
2014
We recently reported the discovery of AMG 232 (1), a potent and selective piperidinone inhibitor of the MDM2-p53 protein-protein… (More)
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2014
2014
We previously reported the discovery of AMG 232, a highly potent and selective piperidinone inhibitor of the MDM2-p53 interaction… (More)
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2014
2014
Structure-based rational design and extensive structure-activity relationship studies led to the discovery of AMG 232 (1), a… (More)
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