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AM841

 
National Institutes of Health

Papers overview

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2020
2020
Highly Selective, Amine-Derived Cannabinoid Receptor 2 Probes.
The endocannabinoid (eCB) system is implied in various human diseases ranging from central nervous system to autoimmune disorders… Expand
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Highly Cited
2017
Highly Cited
2017
Crystal structures of agonist-bound human cannabinoid receptor CB1
The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ9… Expand
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2017
2017
Human Cannabinoid Receptor 2 Ligand-Interaction Motif: Transmembrane Helix 2 Cysteine, C2.59(89), as Determinant of Classical Cannabinoid Agonist Activity and Binding Pose.
Cannabinoid receptor 2 (CB2R)-dependent signaling is implicated in neuronal physiology and immune surveillance by brain microglia… Expand
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2015
2015
AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner.
BACKGROUND AND PURPOSE Cannabinoid (CB) ligands have been demonstrated to have utility as novel therapeutic agents for the… Expand
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2015
2015
In vitro and non-invasive in vivo effects of the cannabinoid-1 receptor agonist AM841 on gastrointestinal motor function in the rat.
BACKGROUND Cannabinoids have been traditionally used for the treatment of gastrointestinal (GI) symptoms, but the associated… Expand
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2014
2014
Cannabinoids Alleviate Experimentally Induced Intestinal Inflammation by Acting at Central and Peripheral Receptors
BACKGROUND AND AIMS In an attempt to further investigate the role of cannabinoid (CB) system in the pathogenesis of inflammatory… Expand
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Highly Cited
2010
Highly Cited
2010
A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor.
Recent isothiocyanate covalent labeling studies have suggested that a classical cannabinoid, (-)-7'-isothiocyanato-11-hydroxy-1… Expand
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2005
2005
(-)-7'-Isothiocyanato-11-hydroxy-1',1'-dimethylheptylhexahydrocannabinol (AM841), a high-affinity electrophilic ligand, interacts covalently with a cysteine in helix six and activates the CB1…
The CB1 cannabinoid receptor has been shown to play important physiological roles in the central nervous system, as well as… Expand
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