AM-8553

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2012-2014
012320122014

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2014
2014
We recently reported the discovery of AM-8553 (1), a potent and selective piperidinone inhibitor of the MDM2-p53 interaction… (More)
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2012
2012
The development of the structurally complex MDM2/p53 inhibitor AM-8553 was impeded by the low yield of the initial synthesis. A… (More)
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2012
2012
p53 is a tumor suppressor and plays a key role in preventing tumor development. In p53 wild-type tumor cells, its tumor… (More)
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2012
2012
Structure-based rational design led to the discovery of novel inhibitors of the MDM2-p53 protein-protein interaction. The… (More)
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