Skip to search formSkip to main contentSkip to account menu

ALS-8176

Known as: ALS-008176 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Meeting report: 29th International Conference on Antiviral Research in La Jolla, CA, USA.
2017
2017
Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase.
Human respiratory syncytial virus (RSV) is a negative-sense RNA virus and a significant cause of respiratory infection in infants… 
Review
2016
Review
2016
New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase.
2016
2016
ALS-008176 for Respiratory Syncytial Virus Infection.
The authors reply: A family history of cancer is a key component in identifying an underlying cancer-predisposition syndrome… 
2016
2016
ALS-008176 for Respiratory Syncytial Virus Infection.
Review
2016
Review
2016
Meeting report: 29th International Conference on Antiviral Research in La Jolla, CA, USA
2016
2016
ALS-008176 for Respiratory Syncytial Virus Infection
Highly Cited
2015
Highly Cited
2015
Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection.
Respiratory syncytial virus (RSV) is a leading pathogen of childhood and is associated with significant morbidity and mortality… 
Highly Cited
2015
Highly Cited
2015
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate
Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections, yet no vaccines or effective therapeutics are… 
2014
2014
LB-1Treatment with Oral ALS-008176, a Nucleoside Analog, Rapidly Reduces RSV Viral Load and Clinical Disease Severity in a Healthy Volunteer Challenge Study
LB-1. Treatment with Oral ALS-008176, a Nucleoside Analog, Rapidly Reduces RSV Viral Load and Clinical Disease Severity in a… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)