ALPL wt Allele

Known as: AP-TNAP, TNAP, APTNAP 
Human ALPL wild-type allele is located in the vicinity of 1p36.12 and is approximately 69 kb in length. This allele, which encodes alkaline… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2018
0102019872018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
We have recently identified 2 distinct CD271(bright)MSCA-1(dim)CD56(+) and CD271(bright)MSCA-1(bright)CD56(-) MSC subsets in… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2009
Highly Cited
2009
AIMS Joint inflammation leads to bone erosion in rheumatoid arthritis (RA), whereas it induces new bone formation in… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2009
2009
Activation-induced cytidine deaminase (AID), the only enzyme that is known to be able to induce mutations in the human genome, is… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
The presence of skeletal hypomineralization was confirmed in mice lacking the gene for bone alkaline phosphatase, ie, the tissue… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
The human tissue nonspecific alkaline phosphatase (TNAP) is found in liver, kidney, and bone. Mutations in the TNAP gene can lead… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Tissue-nonspecific alkaline phosphatase (TNAP) is essential for bone matrix mineralization, but the central mechanism for TNAP… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • figure 5
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Hypophosphatasia is an inborn error of metabolism characterized by deficient activity of the tissue-nonspecific isoenzyme of… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
We report the inactivation, via homologous recombination, of two of the three active mouse alkaline phosphatase genes, i.e… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Mouse primordial germ cells express tissue non-specific alkaline phosphatase (TNAP) during development, but the widespread… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
1992
Highly Cited
1992
Hypophosphatasia is a heritable form of rickets/osteomalacia with extremely variable clinical expression. Severe forms are… (More)
Is this relevant?