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ALPL wt Allele

Known as: AP-TNAP, TNAP, APTNAP 
Human ALPL wild-type allele is located in the vicinity of 1p36.12 and is approximately 69 kb in length. This allele, which encodes alkaline… 
National Institutes of Health

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DephosphorylationHydrolysis

Papers overview

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2020
2020
Pharmacological TNAP inhibition efficiently inhibits arterial media calcification in a warfarin rat model but deserves careful consideration of potential physiological bone formation/mineralization…
2014
2014
Stratified organization and disorganization of inner plexiform layer revealed by TNAP activity in healthy and diabetic rat retina
Tissue non-specific alkaline phosphatase (TNAP), an abundant ectophosphatase, is present in various organs including the brain… 
2013
2013
Inhibitors of tissue-nonspecific alkaline phosphatase: design, synthesis, kinetics, biomineralization and cellular tests.
2012
2012
Enhanced charge transfer in a monolayer of the organic charge transfer complex TTF–TNAP on Au(111)
Electronic doping is a key concept for tuning the properties of organic materials. In bulk structures, the charge transfer… 
2010
2010
Do cytokines induce vascular calcification by the mere stimulation of TNAP activity?
2010
2010
Genetic Etiology and Dental Pulp Cell Deficiency of Hypophosphatasia
Hypophosphatasia is caused by mutations of the tissue-non-specific alkaline phosphatase (TNSALP) gene with deficiency of dentin… 
2008
2008
No significant association between genetic polymorphisms in the TNAP gene and ankylosing spondylitis in the Chinese Han population
The aim of this study was to investigate the association of single nucleotide polymorphisms (SNPs) in tissue non-specific… 
2006
2006
High Level Expression of Tissue-Nonspecific Alkaline Phosphatase in the Milk of Transgenic Rabbits
Alkaline phosphatase is a promising therapeutic agent in the Gram-negative bacterial lipopolysaccharide (LPS) mediated acute and… 
2004
2004
The mutant (F310L and V365I) tissue-nonspecific alkaline phosphatase gene from hypophosphatasia.
Hypophosphatasia (HOPS) is a heritable disorder characterized by defective skeletal mineralization, deficiency of tissue… 
1996
1996
Retinoic acid and methylation cis-regulatory elements control the mouse tissue non-specific alkaline phosphatase gene expression
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