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AKT1S1 wt Allele

Known as: AKT1 Substrate 1 (Proline-Rich) wt Allele, PRAS40, MGC2865 
Human AKT1S1 wild-type allele is located in the vicinity of 19q13.33 and is approximately 9 kb in length. This allele, which encodes proline-rich… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Hyperglycemia induces a wide array of signaling pathways in the kidney that lead to hypertrophy and matrix expansion, eventually… Expand
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Highly Cited
2011
Highly Cited
2011
Reducing the mammalian target of rapamycin (mTOR) activity increases lifespan and health span in a variety of organisms… Expand
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Highly Cited
2009
Highly Cited
2009
PIM1 is a serine/threonine kinase that has diverse biological roles in cell survival, proliferation and differentiation. PIM1 has… Expand
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Highly Cited
2007
Highly Cited
2007
Insulin stimulates protein synthesis and cell growth by activation of the protein kinases Akt (also known as protein kinase B… Expand
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Highly Cited
2007
Highly Cited
2007
The heterotrimeric mTORC1 protein kinase nucleates a signaling network that promotes cell growth in response to insulin and… Expand
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Highly Cited
2007
Highly Cited
2007
The proline-rich Akt substrate of 40 kilodaltons (PRAS40) was identified as a raptor-binding protein that is phosphorylated… Expand
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Highly Cited
2007
Highly Cited
2007
Mammalian target of rapamycin (mTOR) functions in two distinct signaling complexes, mTORC1 and mTORC2. In response to insulin and… Expand
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Highly Cited
2007
Highly Cited
2007
Signaling through the mammalian target of rapamycin complex 1 (mTORC1) is positively regulated by amino acids and insulin. PRAS40… Expand
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Highly Cited
2007
Highly Cited
2007
TOR (Target of Rapamycin) is a highly conserved protein kinase and a central controller of cell growth. TOR is found in two… Expand
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Highly Cited
2003
Highly Cited
2003
Akt (also called protein kinase B) is one of the major downstream targets of the phosphatidylinositol 3-kinase pathway. This… Expand
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