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AKT1S1 wt Allele

Known as: AKT1 Substrate 1 (Proline-Rich) wt Allele, PRAS40, MGC2865 
Human AKT1S1 wild-type allele is located in the vicinity of 19q13.33 and is approximately 9 kb in length. This allele, which encodes proline-rich… 
National Institutes of Health

Related topics

Related topics

2 relations
19q13.33Signal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Targeting PRAS40 for multiple diseases.
2015
2015
Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways.
2014
2014
Phosphorylation of PRAS40‐Thr246 Involved in Renal Lipid Accumulation of Diabetes
Lipid accumulation of kidney is a threat to renal physiological function of diabetes. The previous studies on diabetic… 
2013
2013
Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells
Aims/hypothesisThe proline-rich Akt substrate of 40 kDa (PRAS40) is a component of the mammalian target of rapamycin complex 1… 
2012
2012
Evaluation of 2-Deoxy-2-[18F]Fluoro-D-glucose- and 3′-Deoxy-3′-[18F]Fluorothymidine–Positron Emission Tomography as Biomarkers of Therapy Response in Platinum-Resistant Ovarian Cancer
PurposeWe evaluated whether 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) positron… 
2012
2012
Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem-cell differentiation.
Embryoid bodies (EBs) are three-dimensional multicellular aggregates allowing the in vitro investigation of stem-cell… 
2011
2011
Calcineurin Inhibitor-Induced and Ras-Mediated Overexpression of VEGF in Renal Cancer Cells Involves mTOR through the Regulation of PRAS40
Malignancy is a major problem in patients treated with immunosuppressive agents. We have demonstrated that treatment with… 
2011
2011
microRNA-21 ORCHESTRATES HIGH GLUCOSE-INDUCED SIGNALS TO TORC 1 FOR RENAL CELL PATHOLOGY IN DIABETES
Hyperglycemia induces a wide array of signaling pathways in the kidney that lead to hypertrophy and matrix expansion, eventually… 
2008
2008
The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK.
PRAS40 binds to the mTORC1 (mammalian target of rapamycin complex 1) and is released in response to insulin. It has been… 
Highly Cited
2006
Highly Cited
2006
Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet–Fed Rats
Clinical insulin resistance is associated with decreased activation of phosphatidylinositol 3′-kinase (PI3K) and its downstream… 
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