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AIMP2 gene

Known as: JTV1, AIMP2, AMINOACYL tRNA SYNTHETASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 2 
This gene plays a role in the regulation of both ubiquitination and translation.
National Institutes of Health

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AIMP2 wt Allele
Genetic Translation ProcessRNA ProcessingUbiquitination

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Ratio of Autoantibodies of Tumor Suppressor AIMP2 and Its Oncogenic Variant Is Associated with Clinical Outcome in Lung Cancer
Aminoacyl-tRNA synthetase-interacting multi-functional protein 2 (AIMP2) works as potent tumor suppressor, while its splicing… 
2016
2016
Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor-Suppressive Interaction with Smurf2.
AIMP2/p38 is a multifunctional tumor suppressor that normally resides in the cytosol as a scaffold protein of the multi-tRNA… 
Highly Cited
2015
Highly Cited
2015
Assembly of Multi-tRNA Synthetase Complex via Heterotetrameric Glutathione Transferase-homology Domains*
Background: GST domains have been found in diverse proteins involved in translational systems. Results: Four GST domains from… 
2013
2013
Prostaglandin E2 promotes liver cancer cell growth by the upregulation of FUSE-binding protein 1 expression.
Liver cancer is a common human cancer with a high mortality rate and currently there is no effective chemoprevention or… 
Highly Cited
2012
Highly Cited
2012
Splicing variant of AIMP2 as an effective target against chemoresistant ovarian cancer.
Chemoresistance is a main cause for the failure of cancer management and intensive investigation is on-going to control… 
2012
2012
Selective regression of cancer cells expressing a splicing variant of AIMP2 through targeted RNA replacement by trans-splicing ribozyme.
Highly Cited
2009
Highly Cited
2009
AIMP2 promotes TNFα-dependent apoptosis via ubiquitin-mediated degradation of TRAF2
AIMP2 (aminoacyl-tRNA synthetase interacting multifunctional protein 2; also known as JTV-1) was first identified as p38 in a… 
2009
2009
Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis.
Aminoacyl-transfer ribonucleic acid (tRNA) synthetases-interacting multifunctional protein (AIMP) 2 is a factor associated with… 
Highly Cited
2008
Highly Cited
2008
Autophagy-mediated clearance of aggresomes is not a universal phenomenon.
Aggresomes are juxtanuclear inclusion bodies that have been proposed to act as staging grounds for the disposal of protein… 
Highly Cited
2004
Highly Cited
2004
Gene Expression Analysis of Tumor Spheroids Reveals a Role for Suppressed DNA Mismatch Repair in Multicellular Resistance to Alkylating Agents
ABSTRACT Drug resistance is a major obstacle in the successful treatment of cancer. Thus, elucidation of the mechanisms… 
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