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AHN 1055

Known as: AHN-1055, AHN1055 
 
National Institutes of Health

Papers overview

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2013
2013
Substituting a long‐acting dopamine uptake inhibitor for cocaine prevents relapse to cocaine seeking
The treatment of cocaine addiction remains a challenge. The dopamine replacement approach in cocaine addiction involves the use… Expand
2011
2011
Therapeutic-like properties of a dopamine uptake inhibitor in animal models of amphetamine addiction.
N-substituted benztropine (BZT) analogs are molecules that display high affinity for the dopamine transporter (DAT), therapeutic… Expand
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2009
2009
A dopamine transport inhibitor with markedly low abuse liability suppresses cocaine self-administration in the rat
RationaleN-substituted benztropine analogs are potent dopamine uptake inhibitors that display pharmacokinetic/dynamic properties… Expand
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2009
2009
The Dopamine Uptake Inhibitor 3α-[bis(4′-fluorophenyl)metoxy]-tropane Reduces Cocaine-Induced Early-Gene Expression, Locomotor Activity, and Conditioned Reward
Benztropine (BZT) analogs, a family of high-affinity dopamine transporter ligands, are molecules that exhibit pharmacological and… Expand
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2005
2005
Pharmacodynamic Assessment of the Benztropine Analogues AHN-1055 and AHN-2005 Using Intracerebral Microdialysis to Evaluate Brain Dopamine Levels and Pharmacokinetic/Pharmacodynamic Modeling
No HeadingPurpose.The benztropine (BZT) analogues bind with high affinity to the dopamine transporter (DAT) and demonstrate a… Expand
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2002
2002
Determination of the benztropine analog AHN-1055, a dopamine uptake inhibitor, in rat plasma and brain by high-performance liquid chromatography with ultraviolet absorbance detection.
N-Substituted 3alpha-[bis(4'-fluorophenyl)methoxy] tropanes represent a series of novel potential cocaine abuse therapeutics. AHN… Expand
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