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AGPAT2 gene

Known as: LPAAT-BETA, 1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 2, lysophosphatidic acid acyltransferase, beta 
National Institutes of Health

Papers overview

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2020
2020
Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation
Seipin deficiency causes severe congenital generalized lipodystrophy (CGL) and metabolic disease. However, how seipin regulates… 
2019
2019
Dengue virus reduces AGPAT1 expression to alter phospholipids and enhance infection in Aedes aegypti
More than half of the world population is at risk of dengue virus (DENV) infection because of the global distribution of its… 
2018
2018
A Single Complex Agpat2 Allele in a Patient With Partial Lipodystrophy
Genetic lipodystrophies are a group of rare syndromes associated with major metabolic complications – including severe insulin… 
2016
2016
Identification of a Novel deletion Mutation in AGPAT2 Gene Associated with Congenital Generalized LiPodystrophy Type 1
III Abstract of Arabic IV Declaration V Dedication VI Acknowledgment VII Abbreviation VIII List of Figures IX List of tables X… 
Highly Cited
2015
Highly Cited
2015
Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis
2012
2012
Identification and Characterisation of a Novel Pathogenic Mutation in the Human Lipodystrophy Gene AGPAT2
Loss-of-function mutations in AGPAT2, encoding 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2), produce congenital… 
Highly Cited
2009
Highly Cited
2009
Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy.
Highly Cited
2006
Highly Cited
2006
A Regulatory Role for 1-Acylglycerol-3-phosphate-O-acyltransferase 2 in Adipocyte Differentiation*
Mutations in the 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) gene have been identified in individuals affected with… 
Highly Cited
2005
Highly Cited
2005
Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy.
Highly Cited
2003
Highly Cited
2003
Genetic and phenotypic heterogeneity in patients with mandibuloacral dysplasia-associated lipodystrophy.
Mandibuloacral dysplasia (MAD) is a phenotypically heterogeneous, rare autosomal recessive disorder characterized by mandibular… 
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