AGI-5198
National Institutes of Health
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Patients with mutant IDH1 gliomas survive ~3.8 year longer than patients harboring wildtype IDH1 glioma, irrespective of…
Cholangiocarcinoma is a life‐threatening disease with a poor prognosis. Although genome analysis unraveled some genetic mutation…
Isocitrate dehydrogenase 1 (IDH1) is mutated in various types of human cancer and predicts improved response to treatment with…
Magnetic resonance spectroscopy (MRS) studies have identified elevated levels of the phospholipid precursor phosphocholine (PC…
Background: AGI-5198 (a specific IDH1mut inhibitor) inhibits the formation of D-2-hydroxyglutarate (D-2HG) typically produced in…
Somatic mutations in genes encoding isocitrate dehydrogenase isoforms IDH1 and IDH2 have recently been found in 50–80% of human…
Somatic mutations in genes encoding isocitrate dehydrogenase isoforms IDH1 and IDH2 have recently been found in 50–80% of human…
Somatic mutations in genes encoding isocitrate dehydrogenase isoforms IDH1 and IDH2 have recently been found in 50–80% of human…
Somatic mutations in genes encoding isocitrate dehydrogenase isoforms IDH1 and IDH2 have recently been found in 50–80% of human…
Somatic mutations in genes encoding isocitrate dehydrogenase isoforms IDH1 and IDH2 have recently been found in 50–80% of human…