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AG2037
A water soluble antifolate with anti-proliferative activity. AG2037 inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the…
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National Institutes of Health
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2 relations
Phosphoribosylglycinamide formyltransferase
pelitrexol
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2004
2004
Results of 2 phase I studies of intravenous (iv) pelitrexol (AG2037), a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, in patients (pts) with solid tumors
F. Robert
,
C. Garrett
,
+5 authors
S. Reich
2004
Corpus ID: 198380463
3075 Background: AG2037 is a rationally designed, novel inhibitor of GARFT, which is an essential enzyme in the de novo synthesis…
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2004
2004
Methylthioadenosine (MTA) increases the therapeutic window of AG2037 in MTAP-deficient tumors
Joseph H. Kingtree
,
Gabriel E Troche
,
Xiaohong Yang
,
J. Higgins
,
Donna G. Weller
,
L. A. Bloom
2004
Corpus ID: 91058149
4628 Due to inherent resistance of human cancers, the clinical response rate for most of these tumors is often low even at the…
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