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AG 331

Known as: AG-331 
National Institutes of Health

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Papers overview

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2009
2009
Cytotoxic and biochemical implications of combining AZT and AG-331
We have reported that noncytotoxic concentrations of 3′-azido-3′-deoxythymidine (AZT) increase the cytotoxicity of ICI Dl694, a… 
2007
2007
Tank Mixing Chemicals Applied to Peanut Crops : Are the Chemicals Compatible ?
  • 2007
  • Corpus ID: 21484601
yield and quality. Applying combinations of agrichemicals is an efficient practice with known benefits. Producers may reduce the… 
2004
2004
Biological activity of a novel rationally designed lipophilic thymidylate synthase inhibitor
AG-331 {N6[4-(N-morpholinosulfonyl)benzyl]-N6-methyl-2,6-diamino-benz[cd]indole glucuronate} is a novel lipophilic thymidylate… 
2003
2003
Detection of thymidylate synthase modulators by a novel screening assay.
Thymidylate synthase (TS), a key cancer chemotherapeutic target, catalyzes the conversion of deoxyuridylate to thymidylate. TS… 
Highly Cited
1995
Highly Cited
1995
Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression.
The effects of de novo dTMP inhibition by N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2- thenoyl)-L… 
1995
1995
Biochemical modulation of iododeoxyuridine by N6-[4-(morpholinosulfonyl)benzyl]-N6-methyl-2,6-diaminobenz[cd]indole glucuronate (AG-331) leading to enhanced cytotoxicity.
1995
1995
High-performance liquid chromatographic method for the determination of AG-331, a novel anti-cancer agent, in human serum and urine using solid-phase extraction and photodiode-array detection.
Review
1995
Review
1995
Commentary (Pazdur): New Anticancer Agents in Clinical Development
The article by Eckardt et al reviews numerous anticancer drugs presently undergoing clinical development in the United States… 
1994
1994
Product development of AG-331 lyophilized powder for injection.
AG-331, a water-soluble glucuronate salt of a potential anticancer drug, was synthesized using a technology described as "Protein… 
Review
1993
Review
1993
Enhancement of thymidylate synthase inhibition
Molecular modeling techniques and a knowledge of thymidylate synthase protein structure have assisted in the development of… 
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