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AFP464

A synthetic lysyl prodrug of the amino-substituted flavone derivate aminoflavone with antiproliferative and antineoplastic activities. AFP464 is… 
National Institutes of Health

Papers overview

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2016
2016
Abstract 4983: Aminoflavone acts as an immunomodulator of tumor growth in a breast cancer mouse model
Aminoflavone (AFP464, NSC 710464), an antitumor agent which recently entered phase II clinical trials, acts against estrogen… 
2014
2014
Abstract 215: Aminoflavone exhibits in vivo efficacy on cancer stem cells in a spontaneous estrogen-dependent breast cancer murine model
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Stem-cell populations have been identified in a range of… 
2010
2010
Phase I accelerated dose-escalating safety and pharmacokinetic (PK) study of aryl-hydrocarbon receptor-mediated aminoflavone prodrug AFP464 in advanced solid tumors.
2561 Background: AFP464 is a dimethanesulfonate derivative of aminoflavone that has strong anti-tumor activity against a variety… 
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