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AEB071

Known as: AEB 071 
 
National Institutes of Health

Papers overview

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2014
2014
Targeting B-cell receptor (BCR) signaling in chronic lymphocytic leukemia (CLL) has been successful with durable remissions… Expand
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2014
2014
9030 Background: Uveal melanoma is characterized by frequent mutations in GNAQ or GNA11 that encode for G-protein α-subunits (G… Expand
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2014
2014
G-protein mutations are one of the most common mutations occurring in uveal melanoma activating the protein kinase C (PKC… Expand
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2014
2014
The migration and invasion characteristics that are related to inflammatory response play important roles in the development of… Expand
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2011
2011
Protein kinase C (PKC) isotypes have emerged as key targets for the blockade of early T-cell activation. Herein, we report on the… Expand
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2010
2010
NVP-AEB071 (AEB, sotrastaurin), an oral inhibitor of protein kinase C (PKC), effectively blocks T-cell activation. The… Expand
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Highly Cited
2009
Highly Cited
2009
There is a pressing need for immunosuppressants with an improved safety profile. The search for novel approaches to blocking T… Expand
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2009
2009
A series of novel maleimide-based inhibitors of protein kinase C (PKC) were designed, synthesized, and evaluated. AEB071 (1) was… Expand
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Highly Cited
2008
Highly Cited
2008
PKC isoforms tau, alpha, and beta play fundamental roles in the activation of T cells and other immune cell functions. Here we… Expand
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Review
2008
Review
2008
The first decade of the new millennium has been disappointing for transplant therapeutics: no new immunosuppression agents have… Expand
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