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AEB071

Known as: AEB 071 
National Institutes of Health

Papers overview

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2014
2014
Targeting B-cell receptor (BCR) signaling in chronic lymphocytic leukemia (CLL) has been successful with durable remissions… Expand
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Highly Cited
2014
Highly Cited
2014
The migration and invasion characteristics that are related to inflammatory response play important roles in the development of… Expand
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Highly Cited
2012
Highly Cited
2012
Somatic GNAQ mutations at codon 209 have been identified in approximately 50% of uveal melanomas and have been reported to be… Expand
2011
2011
Protein kinase C (PKC) isotypes have emerged as key targets for the blockade of early T-cell activation. Herein, we report on the… Expand
2010
2010
NVP‐AEB071 (AEB, sotrastaurin), an oral inhibitor of protein kinase C (PKC), effectively blocks T‐cell activation. The… Expand
2010
2010
Inhibition of T-cell activation is the most efficient way to prevent transplant rejection. Protein kinase C (PKC) is an important… Expand
Highly Cited
2009
Highly Cited
2009
There is a pressing need for immunosuppressants with an improved safety profile. The search for novel approaches to blocking T… Expand
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Highly Cited
2009
Highly Cited
2009
A series of novel maleimide-based inhibitors of protein kinase C (PKC) were designed, synthesized, and evaluated. AEB071 (1) was… Expand
Highly Cited
2008
Highly Cited
2008
PKC isoforms tau, alpha, and beta play fundamental roles in the activation of T cells and other immune cell functions. Here we… Expand
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Review
2008
Review
2008
  • F. Vincenti, A. Kirk
  • American journal of transplantation : official…
  • 2008
  • Corpus ID: 205845105
The first decade of the new millennium has been disappointing for transplant therapeutics: no new immunosuppression agents have… Expand