AEB071

Known as: AEB 071 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2008-2017
02420082017

Papers overview

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2014
2014
Targeting B-cell receptor (BCR) signaling in chronic lymphocytic leukemia (CLL) has been successful with durable remissions… (More)
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2014
2014
G-protein mutations are one of the most common mutations occurring in uveal melanoma activating the protein kinase C (PKC… (More)
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2012
2012
Somatic GNAQ mutations at codon 209 have been identified in approximately 50% of uveal melanomas and have been reported to be… (More)
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2012
2012
We examined the effect of the protein kinase C-selective inhibitor AEB071 (sotrastaurin) on neutrophil functions in vitro. Pre… (More)
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2010
2010
NVP-AEB071 (AEB, sotrastaurin), an oral inhibitor of protein kinase C (PKC), effectively blocks T-cell activation. The… (More)
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2010
2010
UNLABELLED BACKGROUND. The novel immunosuppressive agent AEB071 is currently being evaluated for its capability to prevent… (More)
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2009
2009
A series of novel maleimide-based inhibitors of protein kinase C (PKC) were designed, synthesized, and evaluated. AEB071 (1) was… (More)
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2009
2009
There is a pressing need for immunosuppressants with an improved safety profile. The search for novel approaches to blocking T… (More)
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2009
2009
BACKGROUND AEB-071 (AEB) is a specific inhibitor of protein kinase C, which prevents T-lymphocyte activation. The present study… (More)
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Highly Cited
2008
Highly Cited
2008
PKC isoforms tau, alpha, and beta play fundamental roles in the activation of T cells and other immune cell functions. Here we… (More)
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