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AEB071

Known as: AEB 071 
National Institutes of Health

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2 relations
Sotrastaurin Acetate

Broader (1)

sotrastaurin

Papers overview

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2018
2018
Enhanced interaction between SEC2 mutant and TCR Vβ induces MHC II–independent activation of T cells via PKCθ/NF-κB and IL-2R/STAT5 signaling pathways
SEC2, a major histocompatibility complex class II (MHC II)-dependent T-cell mitogen, binds MHC II and T-cell receptor (TCR) Vβs… 
2012
2012
Sotrastaurin (AEB071) Alone and in Combination With Cyclosporine A Prolongs Survival Times of Non-Human Primate Recipients of Life-Supporting Kidney Allografts
Background. Sotrastaurin (STN), a novel oral protein kinase C inhibitor that inhibits early T-cell activation, was assessed in… 
2012
2012
Sotrastaurin, a new selective protein kinase C inhibitor, on the way.
The protein kinase Cs (PKCs), a family of serine-/ threonine-specific protein kinases, are involved in diverse signal… 
2011
2011
Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.
Protein kinase C (PKC) isotypes have emerged as key targets for the blockade of early T-cell activation. Herein, we report on the… 
2010
2010
AEB-071 versus tacrolimus monotherapy to prevent acute cardiac allograft rejection in the rat: a preliminary report.
2010
2010
Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720
NVP‐AEB071 (AEB, sotrastaurin), an oral inhibitor of protein kinase C (PKC), effectively blocks T‐cell activation. The… 
2010
2010
Effects of the new immunosuppressive agent AEB071 on human immune cells.
UNLABELLED BACKGROUND. The novel immunosuppressive agent AEB071 is currently being evaluated for its capability to prevent… 
Review
2010
Review
2010
Overview of sotrastaurin clinical pharmacokinetics.
Sotrastaurin (AEB071) is an investigational immunosuppressant that blocks T-lymphocyte activation through protein kinase C… 
2009
2009
Protein Kinase C Inhibitor, AEB-071, Acts Complementarily With Cyclosporine to Prevent Islet Rejection in Rats
Background. AEB-071 (AEB) is a specific inhibitor of protein kinase C, which prevents T-lymphocyte activation. The present study… 
Review
2009
Review
2009
AEB071 – a promising immunosuppressive agent
Abstract: In the past decades, allograft survival improved because of the development of new and more specific immunosuppressive… 
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