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ACLY gene

Known as: CLATP, ATP citrate lyase, ATP citrate synthase 
This gene is involved in acetyl-CoA metabolism.
National Institutes of Health

Related topics

Related topics

3 relations
ACLY wt AlleleATP Citrate (pro-S)-LyaseATP-Citrate Synthase, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis.
Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for prevention and treatment are urgently needed… 
Highly Cited
2016
Highly Cited
2016
ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch.
Highly Cited
2015
Highly Cited
2015
Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
Macrophage activation/polarization to distinct functional states is critically supported by metabolic shifts. How polarizing… 
Highly Cited
2013
Highly Cited
2013
Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.
Highly Cited
2013
Highly Cited
2013
In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.
Highly Cited
2013
Highly Cited
2013
ATP-citrate lyase is essential for macrophage inflammatory response.
Highly Cited
2013
Highly Cited
2013
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
The MYC genes are the most frequently activated oncogenes in human tumors and are hence attractive therapeutic targets. MYCN… 
Review
2012
Review
2012
ATP-citrate lyase: a key player in cancer metabolism.
ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl CoA from citrate. Acetyl CoA is a vital… 
Review
2010
Review
2010
Metabolic genes in cancer: their roles in tumor progression and clinical implications.
Highly Cited
2008
Highly Cited
2008
ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.
Enhanced glucose and lipid metabolism is one of the most common properties of malignant cells. ATP citrate lyase (ACLY) is a key… 
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