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ACH-806

National Institutes of Health

Papers overview

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2013
2013
ACH-806, an NS4A Antagonist, Inhibits Hepatitis C Virus Replication by Altering the Composition of Viral Replication Complexes
ABSTRACT Treatment of hepatitis C patients with direct-acting antiviral drugs involves the combination of multiple small-molecule… 
2008
2008
Selection of Replicon Variants Resistant to ACH-806, a Novel Hepatitis C Virus Inhibitor with No Cross-Resistance to NS3 Protease and NS5B Polymerase Inhibitors
ABSTRACT We have discovered a novel class of compounds active against hepatitis C virus (HCV), using a surrogate cellular system… 
2008
2008
Synergy of a Hepatitis C Virus (HCV) NS4A Antagonist in Combination with HCV Protease and Polymerase Inhibitors
ABSTRACT Rapid emergence of resistance to monotherapy with virus-specific inhibitors necessitates combination therapy. ACH-806 is… 
2007
2007
[583] ACH-806: A POTENT INHIBITOR OF HCV REPLICATION WITH A NOVEL MECHANISM OF ACTION
2007
2007
[13] IN VITRO EVALUATION OF COMBINATION TREATMENT OF ACH-806 WITH INTERFERON; VX-950 AND NM 107
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