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ABT 526

Known as: ABT-526, ABT526 
 
National Institutes of Health

Papers overview

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2020
2020
Thrombospondin 1 improves hepatic steatosis in diet-induced insulin-resistant mice and is associated with hepatic fat content in humans
Background Nonalcoholic fatty liver disease (NAFLD) is associated with altered production of secreted proteins. Increased… Expand
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Highly Cited
2006
Highly Cited
2006
Preclinical Evaluation of Antiangiogenic Thrombospondin-1 Peptide Mimetics, ABT-526 and ABT-510, in Companion Dogs with Naturally Occurring Cancers
Purpose: The angiogenic phenotype of malignant cancers has been established as a target for cancer therapy. ABT-526 and ABT-510… Expand
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2006
2006
Cooperative Activity of Cytotoxic Chemotherapy with Antiangiogenic Thrombospondin-I Peptides, ABT-526 in Pet Dogs with Relapsed Lymphoma
Purpose: Thrombospondin-I (TSP-I) is a natural antiangiogenic protein that enhances apoptosis of activated endothelial cells. A… Expand
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Highly Cited
2005
Highly Cited
2005
Thrombospondin-1 mimetic peptide inhibitors of angiogenesis and tumor growth: design, synthesis, and optimization of pharmacokinetics and biological activities.
The heptapeptide 1, NAc-Gly-Val-DIle-Thr-Arg-Ile-ArgNHEt, a structurally modified fragment derived from the second type-1 repeat… Expand
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2004
2004
A randomized placebo-controlled pre-clinical trial of the anti-angiogenic thromobspondin-mimetic peptide ABT-526 plus Lomustine chemotherapy versus Lomustine chemotherapy alone in pet dogs with…
3088 Background: Thrombospondin-1 (TSP-1) is a natural antiangiogenic protein that enhances apoptosis of activated endothelial… Expand
Is this relevant?
2004
2004
A randomized placebo-controlled pre-clinical trial of the anti-angiogenic thromobspondin-mimetic peptide ABT-526 plus Lomustine chemotherapy versus Lomustine chemotherapy alone in pet dogs with…
3088 Background: Thrombospondin-1 (TSP-1) is a natural antiangiogenic protein that enhances apoptosis of activated endothelial… Expand
Is this relevant?
2003
2003
Contrasting effects of VEGF gene disruption in embryonic stem cell-derived versus oncogene-induced tumors.
Previous gene targeting studies have implicated an indispensable role of vascular endothelial growth factor (VEGF) in tumor… Expand
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