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ABT 491

Known as: ABT-491 
National Institutes of Health

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2 relations

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ImidazolesIndoles

Papers overview

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2019
2019
Treatment with a platelet‐activating factor receptor antagonist improves hemodynamics and reduces epinephrine requirements, in a lethal rodent model of anaphylactic shock
In some cases, anaphylactic shock (AS) is still lethal, despite rapid use of epinephrine. High doses of epinephrine are… 
2019
2019
Role of phosphorylcholine in Streptococcus pneumoniae and nontypeable Haemophilus influenzae adherence to epithelial cells.
Highly Cited
2018
Highly Cited
2018
Structural basis for signal recognition and transduction by platelet-activating-factor receptor
Platelet-activating-factor receptor (PAFR) responds to platelet-activating factor (PAF), a phospholipid mediator of cell-to-cell… 
2011
2011
Protective Effects of Platelet-Activating Factor Antagonist ABT-491 on the Peripheral Nerves in Hypoxic Ischemia-Induced Neonatal Rat Model
ABS TRACT Ob jec ti ve: Ne o na tal hypo xic-isc he mic (HI) in sult has acu te and long term de le te ri o us ef fects on many… 
2009
2009
The influence of platelet activating factor on the effects of platelet agonists and antiplatelet agents in vitro
We assessed the effect of the intercellular mediator of inflammation, platelet activating factor (PAF), on platelet function. The… 
2007
2007
Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury
2006
2006
MCI-186 (edaravone), a free radical scavenger, attenuates ischemia-reperfusion injury and activation of phospholipase A(2) in an isolated rat lung model after 18 h of cold preservation.
1998
1998
The role of platelet-activating factor (PAF) and the efficacy of ABT-491, a highly potent and selective PAF antagonist, in experimental allergic rhinitis.
Platelet-activating factor (PAF) may be an important mediator of allergic rhinitis. In the present study we evaluated the… 
1998
1998
Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists.
Studies conducted with the goal of discovering a second-generation platelet-activating factor (PAF) antagonist have identified a… 
1997
1997
ABT-491, a highly potent and selective PAF antagonist, inhibits nasal vascular permeability associated with experimental allergic rhinitis in Brown Norway rats
Allergic rhinitis is an inflammatory disease of the upper airway. Symptoms of the disease, which include congestion, rhinorrhea… 
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