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Target‐mediated drug disposition (TMDD) is a term to describe a nonlinear pharmacokinetic (PK) phenomenon that is caused by high… Expand Nonlinearities are commonplace in pharmacokinetics, and 1 special source is the saturable binding of the drug to a high‐affinity… Expand Resume La 11β-hydroxysteroide deshydrogenase de type 1 (11βHSD1) est une enzyme intervenant dans la transformation tissulaire de… Expand Nonlinearities are frequently encountered in pharmacokinetics, and they can occur when 1 or more processes of absorption… Expand In this study we assessed increased cortisol in Alzheimer's disease (AD) patients. The selective 11‐β‐hydroxysteroid… Expand ABT‐384 is a potent and selective inhibitor of 11β‐hydroxysteroid dehydrogenase type 1 (HSD‐1). The pharmacokinetics of ABT‐384… Expand ABT‐384 is a potent and selective inhibitor of 11β‐hydroxysteroid dehydrogenase type 1 (HSD‐1), the enzyme that regenerates… Expand ABT-384 is a potent, selective inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1 (HSD-1). One milligram of ABT-384 daily… Expand ABT-384 [1-piperazineacetamide, N-[5-(aminocarbonyl) tricyclo[22.214.171.124,7]dec-2-yl]-α,α-dimethyl-4-[5-(trifluoromethyl)-2… Expand