ABT-199

Known as: ABT-0199, ABT199 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2013-2017
020406020132017

Papers overview

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Highly Cited
2015
Highly Cited
2015
Overexpression of anti-apoptotic BCL-2 family members is a hallmark of many lymphoid malignancies, including chronic lymphocytic… (More)
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2015
2015
PURPOSE Bruton's tyrosine kinase (BTK) is a critical enzyme in the B-cell receptor pathway and is inhibited by ibrutinib due to… (More)
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Highly Cited
2014
Highly Cited
2014
B-cell leukemia/lymphoma 2 (BCL-2) prevents commitment to programmed cell death at the mitochondrion. It remains a challenge to… (More)
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2014
2014
Acquired resistance to targeted drugs is emerging as an obstacle to successful cancer treatment. Recently, a BCL2-selective BH3… (More)
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Highly Cited
2014
Highly Cited
2014
7450–7457. 11 Lombardo LJ, Lee FY, Chen P, Norris D, Barrish JC, Behnia K et al. Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6… (More)
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2014
2014
T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype of acute lymphoblastic leukemia (ALL) with gradually improved… (More)
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2014
2014
UNLABELLED Acute lymphoblastic leukemia (ALL) is a hematopoietic malignancy derived from immature B-lymphoid and T-lymphoid cells… (More)
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Highly Cited
2013
Highly Cited
2013
Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are key regulators of the apoptotic process. This family comprises… (More)
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Highly Cited
2013
Highly Cited
2013
The prosurvival protein BCL-2 is frequently overexpressed in estrogen receptor (ER)-positive breast cancer. We have generated ER… (More)
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2013
2013
ABT-199 is a new selective small molecule inhibitor of BCL-2 that appears to spare platelets while achieving potent antitumor… (More)
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