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ABC 294640
Known as:
ABC-294640
, ABC294640
National Institutes of Health
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Sphingosine Kinase-2 Inhibitor ABC294640
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The combination of a sphingosine kinase 2 inhibitor (ABC294640) and a Bcl‐2 inhibitor (ABT‐199) displays synergistic anti‐myeloma effects in myeloma cells without a t(11;14) translocation
P. Sundaramoorthy
,
C. Gasparetto
,
Yubin Kang
Cancer Medicine
2018
Corpus ID: 46886645
Multiple myeloma (MM) remains an incurable disease in need of the development of novel therapeutic agents and drug combinations…
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2017
2017
The sphingosine kinase 2 inhibitor ABC294640 inhibits cervical carcinoma cell growth
Ling Xu
,
L. Jin
,
+4 authors
Jun Xu
OncoTarget
2017
Corpus ID: 5138992
ABC294640 is a specific sphingosine kinase 2 (SphK2) inhibitor. The anti-cervical carcinoma activity by ABC294640 was tested in…
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2017
2017
Inhibition of Sphingosine Kinase-2 by ABC294640 Suppresses Endotoxin-Induced Inflammatory Responses and Apoptosis in Mouse Livers
Y. Krishnasamy
,
J. Lemasters
,
Z. Zhong
2017
Corpus ID: 80102340
2016
2016
Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects.
N. Gardner
,
R. Riley
,
+4 authors
J. G. Gelineau-van Waes
Toxicological Sciences
2016
Corpus ID: 7248607
FTY720 (fingolimod) is a U.S. Food and Drug Administration-approved drug to treat relapsing remitting multiple sclerosis. FTY720…
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2016
2016
Antitumor and anti-inflammatory effects of the sphingosine kinase-2 inhibitor ABC294640 in combination with radiation
Charles D Smith
,
L. Maines
,
+4 authors
C. Green
2016
Corpus ID: 79068598
Review
2016
Review
2016
Supplemental Information Sphingosine kinases : emerging structure-function insights
D. Adams
,
S. Pyne
,
N. Pyne
2016
Corpus ID: 13114463
Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental…
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2014
2014
Sphingosine kinase 2: a controversial role in arthritis
Tao Xu
,
Lin Li
,
Cheng Huang
,
Yunyun Peng
,
Jun Li
Rheumatology International
2014
Corpus ID: 11381039
AbstractSphK2 is a nuclear protein that suppresses cell proliferation by inhibiting DNA synthesis, while also enhancing apoptosis…
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2013
2013
Abstract C62: Phase I trial of ABC294640, a first-in-class sphingosine kinase-2 inhibitor.
M. Thomas
,
C. Britten
,
+8 authors
Charles D Smith
2013
Corpus ID: 85175192
Sphingosine kinases (SK1 and SK2) are new potential targets for anticancer drugs because SK inhibitors elevate ceramide levels…
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2012
2012
Identification of Sphingosine Kinases As Therapeutic Targets in B-Lineage Acute Lymphoblastic Leukemia
C. Wallington-Beddoe
,
K. Bradstock
,
L. Bendall
2012
Corpus ID: 208386628
Abstract 1499 Sphingosine 1-phosphate (S1P) is a bioactive lipid with roles in cell proliferation and survival. S1P is produced…
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2009
2009
Preclinical development of orally available sphingosine kinase inhibitors.
C. Smith
,
L. Maines
,
+5 authors
W. Wang
Journal of Clinical Oncology
2009
Corpus ID: 25220423
e14615 Background: Sphingolipid-metabolizing enzymes control the dynamic balance of important bioactive lipids, including…
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