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ABC 294640

Known as: ABC-294640, ABC294640 
National Institutes of Health

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Sphingosine Kinase-2 Inhibitor ABC294640

Papers overview

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2020
2020
The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells.
2018
2018
The combination of a sphingosine kinase 2 inhibitor (ABC294640) and a Bcl‐2 inhibitor (ABT‐199) displays synergistic anti‐myeloma effects in myeloma cells without a t(11;14) translocation
Multiple myeloma (MM) remains an incurable disease in need of the development of novel therapeutic agents and drug combinations… 
2018
2018
Inhibition of SphK2 Stimulated Hepatic Gluconeogenesis Associated with Dephosphorylation and Deacetylation of STAT3.
2017
2017
The sphingosine kinase 2 inhibitor ABC294640 inhibits cervical carcinoma cell growth
ABC294640 is a specific sphingosine kinase 2 (SphK2) inhibitor. The anti-cervical carcinoma activity by ABC294640 was tested in… 
2016
2016
Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects.
FTY720 (fingolimod) is a U.S. Food and Drug Administration-approved drug to treat relapsing remitting multiple sclerosis. FTY720… 
2016
2016
Antitumor and anti-inflammatory effects of the sphingosine kinase-2 inhibitor ABC294640 in combination with radiation
2014
2014
Sphingosine kinase 2: a controversial role in arthritis
AbstractSphK2 is a nuclear protein that suppresses cell proliferation by inhibiting DNA synthesis, while also enhancing apoptosis… 
2013
2013
Abstract C62: Phase I trial of ABC294640, a first-in-class sphingosine kinase-2 inhibitor.
Sphingosine kinases (SK1 and SK2) are new potential targets for anticancer drugs because SK inhibitors elevate ceramide levels… 
2012
2012
Sphingosine kinase inhibition exerts both pro- and anti-atherogenic effects in low-density lipoprotein receptor-deficient (LDL-R−/−) mice
Summary Sphingosine 1-phosphate (S1P), a lysosphingolipid associated with high-density lipoprotein (HDL), contributes to the anti… 
2012
2012
Identification of Sphingosine Kinases As Therapeutic Targets in B-Lineage Acute Lymphoblastic Leukemia
Abstract 1499 Sphingosine 1-phosphate (S1P) is a bioactive lipid with roles in cell proliferation and survival. S1P is produced… 
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