A498

An adenocarcinoma cell line established from a 52 year old female patient with renal cell carcinoma.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Long non-coding RNA GAS5 functions as a tumor suppressor in renal cell carcinoma.
BACKGROUND Renal cell carcinoma (RCC) is a malignancy with a poor prognosis. We aimed to explore whether the expression of Long… (More)
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Highly Cited
2010
Highly Cited
2010
Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.
The mammalian target of rapamycin (mTOR) is a major component of the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway that… (More)
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Highly Cited
2009
Highly Cited
2009
BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer.
BTG3/ANA/APRO4 has been reported to be a tumor suppressor gene in some malignancies. It constitutes important negative regulatory… (More)
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Highly Cited
2004
Highly Cited
2004
SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.
Clinically, there is a great need for small molecule inhibitors that could control pathogenic effects of transforming growth… (More)
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Highly Cited
2003
Highly Cited
2003
Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL
Organ-specific metastasis is governed, in part, by interactions between chemokine receptors on cancer cells and matching… (More)
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2003
2003
Arsenic trioxide inhibits the growth of A498 renal cell carcinoma cells via cell cycle arrest or apoptosis.
Previously, we showed that arsenic trioxide potently inhibited the growth of myeloma cells and head and neck cancer cells. Here… (More)
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Highly Cited
2002
Highly Cited
2002
Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.
Transforming growth factor beta1 (TGF-beta1) is a potent fibrotic factor responsible for the synthesis of extracellular matrix… (More)
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Highly Cited
2001
Highly Cited
2001
Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts.
Lipid rafts are sphingolipid- and cholesterol-rich membrane microdomains that are insoluble in nonionic detergents, have a low… (More)
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1997
1997
Non-centrosomal microtubule formation and measurement of minus end microtubule dynamics in A498 cells.
Experiments performed on a cell line (A498) derived from a human kidney carcinoma revealed non-centrosomal microtubules in the… (More)
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Highly Cited
1987
Highly Cited
1987
The regulated expression of erythropoietin by two human hepatoma cell lines.
The development of a cell culture system that produces erythropoietin (Epo) in a regulated manner has been the focus of much… (More)
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