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A 278637

Known as: A-278637, A278637 
National Institutes of Health

Papers overview

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2011
2011
Design and efficient synthesis of A-278637 derivatives as potential potassium channel opener.
2004
2004
(−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637), a Novel ATP-Sensitive Potassium Channel Opener: Hemodynamic Comparison to ZD-6169, WAY…
The therapeutic utility of KATP channel opening agents (KCOs) in the treatment of overactive bladder may be limited by… 
2004
2004
Synthesis and structure-activity relationships of a novel series of 2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide K(ATP) channel openers: discovery of (-)-(9S)-9-(3-bromo-4…
Structure-activity relationships were investigated on a novel series of sulfonyldihydropyridine-containing K(ATP) openers. Ring… 
2002
2002
(−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary…
Alterations in the myogenic activity of the bladder smooth muscle are thought to serve as a basis for the involuntary detrusor… 
2002
2002
(−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary…
ATP-sensitive potassium (KATP) channel openers (KCOs) have been shown to inhibit spontaneous myogenic contractile activity of the… 
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