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A-1210477

 
National Institutes of Health

Papers overview

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2019
2019
First-generation bromodomain extra-terminal protein (BETP) inhibitors (BETi) (e.g., OTX015) that disrupt binding of BETP BRD4 to… Expand
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2019
2019
Proteolysis Targeting Chimera (PROTAC) recruits an E3 ligase to a target protein to induce its ubiquitination and subsequent… Expand
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2018
2018
BH3 mimetics are a promising new class of anticancer agents that inhibit antiapoptotic BCL-2 proteins. Here, we report that BH3… Expand
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2018
2018
ObjectiveThere are number of studies which report that BCL-2 anti-apoptotic proteins (e.g. BCL-2, BCL-XL, and MCL-1) are highly… Expand
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Review
2017
Review
2017
BH3-only proteins constitute major proportion of pro-apoptotic members of B-cell lymphoma 2 (Bcl-2) family of apoptotic… Expand
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2017
2017
Acute myeloid leukemia (AML) is a serious disease. The 5-year survival rates remain frustratingly low (65% for children and 26… Expand
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2017
2017
The concept of using BH3 mimetics as anticancer agents has been substantiated by the efficacy of selective drugs, such as… Expand
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Highly Cited
2015
Highly Cited
2015
The anti-apoptotic protein MCL-1 is a key regulator of cancer cell survival and a known resistance factor for small-molecule BCL… Expand
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Highly Cited
2015
Highly Cited
2015
Hyperexpression of antiapoptotic BCL-2 family proteins allows cells to survive despite the receipt of signals that would… Expand
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2015
2015
As a population, non-Hodgkin's lymphoma (NHL) cell lines positive for the t(14;18) translocation and/or possessing elevated BCL2… Expand
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