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9-aminoacridine-4-carboxamide

Known as: 9-AA-4-CA 
National Institutes of Health

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Aminoacridines

Papers overview

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2013
2013
Non-covalent duplex to duplex crosslinking of DNA in solution revealed by single molecule force spectroscopy.
Small molecules that interact with DNA, disrupting the binding of transcription factors or crosslinking DNA into larger… 
2002
2002
The interaction of DNA-targeted 9-aminoacridine-4-carboxamide platinum complexes with DNA in intact human cells.
2001
2001
cis-Dichloroplatinum(II) complexes tethered to 9-aminoacridine-4-carboxamides: synthesis and action in resistant cell lines in vitro.
2000
2000
Acridinecarboxamide topoisomerase poisons: structural and kinetic studies of the DNA complexes of 5-substituted 9-amino-(N-(2-dimethylamino)ethyl)acridine-4-carboxamides.
For a series of antitumor-active 5-substituted 9-aminoacridine-4-carboxamide topoisomerase II poisons, we have used X-ray… 
1992
1992
Sequence specificity of the binding of 9-aminoacridine- and amsacrine-4-carboxamides to DNA studied by DNase I footprinting.
DNase I footprinting has been used to probe the sequence selectivity of binding of a series of intercalating amsacrine-4… 
1991
1991
Synthesis and evaluation of DNA-targeted spatially separated bis(aniline mustards) as potential alkylating agents with enhanced DNA cross-linking capability.
DNA-targeted separated bis-mustards were synthesized by attaching aniline mono-mustards at the 4- and 9-positions of the DNA… 
1988
1988
Energetics and stereochemistry of DNA complexation with the antitumor AT specific intercalators tilorone and m-AMSA.
Computations by the SIBFA method on the intercalative interaction energies of tilorone and m-AMSA with B-DNA representative… 
Highly Cited
1987
Highly Cited
1987
Relationships between DNA-binding kinetics and biological activity for the 9-aminoacridine-4-carboxamide class of antitumor agents.
The kinetics of dissociation of calf thymus DNA complexes of the new intercalating antitumor drug N-[2-(dimethylamino)ethyl]-9… 
1987
1987
Crystallographic and molecular mechanics calculations on the anti-tumor drugs N-[(2-dimethylamino)ethyl]-and N-[(2-dimethyl-amino)butyl]-9-aminoacridine-4-carboxamides and their dications…
The molecular structures of the N-(2-dimethylamino)ethyl and N-(2-dimethylamino)butyl derivatives of 9-aminoacridine-4… 
1987
1987
Groove selectivity in the interaction of 9‐aminoacridine‐4‐carboxamide antitumor agents with DNA
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