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7-methoxy-4-trifluoromethylcoumarin

National Institutes of Health

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Related topics

1 relation

Broader (1)

Coumarins

Papers overview

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2016
2016
Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism
Crystal structures of CYP2B35 and CYP2B37 from the desert woodrat were solved in complex with 4-(4-chlorophenyl)imidazole (4-CPI… 
Review
2010
Review
2010
Cytochrome P450-mediated hepatic metabolism of new fluorescent substrates in cats and dogs.
This study aimed to investigate the biotransformation of cat liver microsomes in comparison to dogs and humans using a high… 
2008
2008
Identification and Analysis of Conserved Sequence Motifs in Cytochrome P450 Family 2
Using a multiple alignment of 175 cytochrome P450 (CYP) family 2 sequences, 20 conserved sequence motifs (CSMs) were identified… 
2006
2006
Influence of Fluorescent Probe Size and Cytochrome b5 on Drug-Drug Interactions in CYP2C9
7-Methoxy-4-trifluoromethylcoumarin (MFC) has been used extensively in high-throughput screens for the identification of… 
2002
2002
CYTOCHROME P 450 FLUOROMETRIC SUBSTRATES : IDENTIFICATION OF ISOFORM-SELECTIVE PROBES FOR RAT CYP 2 D 2 AND HUMAN CYP 3 A 4 .
We have tested a panel of 29 cDNA-expressed rat and human enzymes with 9 fluorometric substrates to determine the P450 isoform… 
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