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5F-203

National Institutes of Health

Papers overview

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2014
2014
Molecular dynamics simulation studies for DNA sequence recognition by reactive metabolites of anticancer compounds
The discovery of novel anticancer molecules 5F‐203 (NSC703786) and 5‐aminoflavone (5‐AMF, NSC686288) has addressed the issues of… 
Review
2012
Review
2012
Cytochrome P450 1A1-mediated anticancer drug discovery: in silico findings
Introduction: Target-specific drugs may offer fewer side/adverse effects in comparison with other anticancer agents and thus save… 
Highly Cited
2011
Highly Cited
2011
CYP2S1 and CYP2W1 Mediate 2-(3,4-Dimethoxyphenyl)-5-Fluorobenzothiazole (GW-610, NSC 721648) Sensitivity in Breast and Colorectal Cancer Cells
Both 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F-203; NSC 703786) and 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW… 
2011
2011
Preclinical Development CYP 2 S 1 and CYP 2 W 1 Mediate 2-( 3 , 4-Dimethoxyphenyl )-5-Fluorobenzothiazole ( GW-610 , NSC 721648 ) Sensitivity in Breast and Colorectal Cancer Cells
Both 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F-203; NSC 703786) and 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW… 
2008
2008
BRCA1 modulates sensitivity to 5F-203 by regulating xenobiotic stress-inducible protein levels and EROD activity
PurposeWe have investigated the effects of BRCA1 over-expression and knockdown on 5F-203-induced gene expression and cytotoxicity… 
2006
2006
Differential Gene Expression as a Potential Classifier of 2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole-Sensitive and -Insensitive Cell Lines
2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole (5F-203) is a candidate antitumor agent empirically discovered with the aid of… 
Highly Cited
2003
Highly Cited
2003
Genotoxic profiling of MCF-7 breast cancer cell line elucidates gene expression modifications underlying toxicity of the anticancer drug 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole.
A candidate antitumor agent, 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F-203), was empirically discovered through the… 
2003
2003
Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity.
A candidate antitumor agent, 2-(4-amino-3-methylphenyl)-5-fluoro-benzothiazole (5F-203), like its non-fluorinated parent compound… 
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