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5-carboxy-8-hydroxyquinoline

Known as: 8-hydroxy-5-quinolinecarboxylic acid, IOX1 compound 
 
National Institutes of Health

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Broader (1)

Hydroxyquinolines

Papers overview

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2015
2015
Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline.
A series of JMJD2A inhibitors had been designed by analyzing the binding mode of 5-carboxy-8-hydroxyquinoline (5-carboxy-8-HQ… Expand
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Highly Cited
2014
Highly Cited
2014
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.
In prostate cancer, two different types of histone lysine demethylases (KDM), LSD1/KDM1 and JMJD2/KDM4, are coexpressed and… Expand
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2014
2014
A Cell-Permeable Ester Derivative of the JmjC Histone Demethylase Inhibitor IOX1
The 2-oxoglutarate (2OG)-dependent Jumonji C domain (JmjC) family is the largest family of histone lysine demethylases. There is… Expand
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Highly Cited
2013
Highly Cited
2013
5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.
2-Oxoglutarate and iron dependent oxygenases are therapeutic targets for human diseases. Using a representative 2OG oxygenase… Expand
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