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5-azacytosine

National Institutes of Health

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2 relations

Broader (1)

Cytosine
analogs & derivatives

Papers overview

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Highly Cited
2018
Highly Cited
2018
Controlled fabrication of well-dispersed AgPd nanoclusters supported on reduced graphene oxide with highly enhanced catalytic properties towards 4-nitrophenol reduction.
Review
2008
Review
2008
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
The cytosine analogues 5‐azacytosine (azacytidine) and 2′‐deoxy‐5‐azacytidine (decitabine) are the currently most advanced drugs… 
Highly Cited
2008
Highly Cited
2008
p21WAF1/CIP1 induction by 5-azacytosine nucleosides requires DNA damage
Decitabine (DAC) and 5-azacitidine have recently been approved for the treatment of myelodysplastic syndrome. The pharmacodynamic… 
Review
2002
Review
2002
5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy
5-Azacytidine was first synthesized almost 40 years ago. It was demonstrated to have a wide range of anti-metabolic activities… 
Review
1994
Review
1994
Biological implications of the mechanism of action of human DNA (cytosine-5)methyltransferase.
  • S. S. Smith
  • Progress in Nucleic Acid Research and Molecular…
  • 1994
  • Corpus ID: 1112038
Highly Cited
1987
Highly Cited
1987
Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2'-deoxycytidine resistance
A clonal cell line (56-42) that was stably and exclusively resistant to the toxic effects of the antileukemic agent 5-aza-2… 
Highly Cited
1984
Highly Cited
1984
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine.
DNA containing 5-azacytosine (azaC) has previously been shown to be a potent inhibitor of DNA-cytosine methyltransferases. In… 
Highly Cited
1982
Highly Cited
1982
Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine.
Highly Cited
1981
Highly Cited
1981
Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells.
Duplex heavy-light (HL) DNAs synthesized in the presence of brdUrd and methylation inhibitors were separated from bulk cellular… 
1979
1979
Synthesis and antitumor activity of 5-azacytosine arabinoside.
5-Azacytosine arabinoside (ara-AC) can be considered a combination of structural elements derived from the antitumor nucleosides… 
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