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5-azacytosine

National Institutes of Health

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2 relations

Broader (1)

Cytosine
analogs & derivatives

Papers overview

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Highly Cited
2012
Highly Cited
2012
Preparation and adsorption performance of 5-azacytosine-functionalized hydrothermal carbon for selective solid-phase extraction of uranium.
A new solid-phase extraction adsorbent was prepared by employing a two-step "grafting from" approach to anchor a multidentate N… Expand
Review
2008
Review
2008
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
The cytosine analogues 5‐azacytosine (azacytidine) and 2′‐deoxy‐5‐azacytidine (decitabine) are the currently most advanced drugs… Expand
Highly Cited
2008
Highly Cited
2008
p21WAF1/CIP1 induction by 5-azacytosine nucleosides requires DNA damage
Decitabine (DAC) and 5-azacitidine have recently been approved for the treatment of myelodysplastic syndrome. The pharmacodynamic… Expand
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Review
2002
Review
2002
5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy
5-Azacytidine was first synthesized almost 40 years ago. It was demonstrated to have a wide range of anti-metabolic activities… Expand
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Highly Cited
1987
Highly Cited
1987
Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2'-deoxycytidine resistance.
A clonal cell line (56-42) that was stably and exclusively resistant to the toxic effects of the antileukemic agent 5-aza-2… Expand
Highly Cited
1984
Highly Cited
1984
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine.
DNA containing 5-azacytosine (azaC) has previously been shown to be a potent inhibitor of DNA-cytosine methyltransferases. In… Expand
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Highly Cited
1982
Highly Cited
1982
Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine.
Treatment of Friend erythroleukemia cells with the antileukemic drugs 5-azacytidine and 5-aza-2'-deoxycytidine leads to rapid… Expand
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Highly Cited
1982
Highly Cited
1982
Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA.
Abstract Hemimethylated DNA substrates prepared from cell cultures treated with 5-azacytidine are efficient acceptors of methyl… Expand
Highly Cited
1981
Highly Cited
1981
Hemimethylated duplex DNAs prepared from 5-azacytidine-treated cells.
Duplex heavy-light (HL) DNAs synthesized in the presence of brdUrd and methylation inhibitors were separated from bulk cellular… Expand
1979
1979
Synthesis and antitumor activity of 5-azacytosine arabinoside.
5-Azacytosine arabinoside (ara-AC) can be considered a combination of structural elements derived from the antitumor nucleosides… Expand
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