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5-FdU

National Institutes of Health

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5-formyl-2'-deoxyuridine

Papers overview

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2018
2018
Abstract 1663: Identification and characterization of a small-molecule inhibitor of the human uracil-DNA glycosylase for use in combination with DNA damage-based anticancer therapies
Our research aims to develop therapeutically active inhibitors of the human uracil-DNA glycosylase (UNG). UNG, a highly conserved… 
2017
2017
The activity of the conjugated antimetabolite 5-FdU-ECyd against platinum-resistant ovarian cancer.
e17077Background: Primary or secondary resistance to platinum-based chemotherapy is an important clinical challenge in the… 
2017
2017
Evaluation der pharmakologischen Wirkung des neuen Antimetabolit-Bisphosphonat-Konjugats 5-FdU-Alendronat auf die ossäre Metastasierung des Mammakarzinoms auf zellulärer Ebene sowie am kliniknahen…
Ziel dieser Dissertation ist es, den neuen kombinierten Wirkstoff 2'-Desoxy-5-Fluoruridin-Alendronat (5-FdU-ale) anhand von in… 
2014
2014
Induction of apoptosis in cervical cancer cells by the duplex drug 5-FdU-ECyd, coupling 2'-deoxy-5-fluorouridine and 3'-C-ethinylcytidine.
2013
2013
Effect of duplex drugs linking 2′-deoxy-5-fluorouridine (5-FdU) with 3′-C-ethynylcytidine (ECyd) on hepatoblastoma cell lines
PurposeDuplex drugs are promising anticancer agents. After in vivo cleavage into active nucleoside analogues, they exert their… 
2011
2011
N⁴-[Alkyl-(hydroxyphosphono)phosphonate]-cytidine-new drugs covalently linking antimetabolites (5-FdU, araU or AZT) with bone-targeting bisphosphonates (alendronate or pamidronate).
2011
2011
ATP chemosensitivity testing of new antitumor duplex drugs linking 3`-C-ethynylycytidine (ECyd) and 2´-deoxy-5-fluorouridine (5-FdU) in comparison to standard cytostatica and combinations thereof
SummaryBackground 2´-Deoxy-5-fluorouridylyl-(5´-5´)-3´-C-ethynylcytidine [5-FdU(5´-5´)ECyd] and 3´-C-ethynylcytidinylyl-(5´->1-O… 
2010
2010
Abstract 2582: Branched neurotensin peptides for the selective targeting of human colon and pancreas carcinoma
The aim of this study was to validate oligo-branched peptides as selective targeting agents that might be effective either for… 
2000
2000
The novel heterodinucleoside dimer 5‐FdU‐NOAC is a potent cytotoxic drug and a p53‐independent inducer of apoptosis in the androgen‐independent human prostate cancer cell lines PC‐3 and DU‐145
We analyzed the cytotoxic properties of the new heterodinucleoside phosphate dimer 5‐FdU‐NOAC, which is composed of the cytotoxic… 
1965
1965
Effects of 5-fluorouracil on photoperiodic induction and nucleic acid metabolism of xanthium.
Salisbury and Bonner (13) have shown that the pyrimidine, 5-fluorouracil (5-FU), when applied either to the apical vegetative bud… 
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