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5-Aminolevulinate Synthase, Nonspecific, Mitochondrial

Known as: 5-Aminolevulinic Acid Synthase 1, Migration-Inducing Protein 4, EC 2.3.1.37 
5-aminolevulinate synthase, nonspecific, mitochondrial (640 aa, ~71 kDa) is encoded by the human ALAS1 gene. This protein plays a role in both… 
National Institutes of Health

Related topics

Related topics

5 relations
ALAS1 geneEnzyme GeneGlycine, Serine and Threonine Metabolism PathwayLipid Metabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1998
1998
Role of arginine 439 in substrate binding of 5-aminolevulinate synthase.
5-Aminolevulinate synthase (EC 2.3.1.37) catalyzes the first reaction in the heme biosynthetic pathway in nonplant eukaryotes and… 
1996
1996
Active site of 5-aminolevulinate synthase resides at the subunit interface. Evidence from in vivo heterodimer formation.
5-Aminolevulinate synthase (EC 2.3.1.37) is the first enzyme in the heme biosynthetic pathway of animals, fungi and some bacteria… 
1995
1995
Regulation of 5-aminolevulinic acid synthesis in Rhodobacter sphaeroides 2.4.1: the genetic basis of mutant H-5 auxotrophy
Rhodobacter sphaeroides H-5 was isolated as a 5-aminolevulinic acid (ALA) auxotroph following treatment of wild-type cells with N… 
1986
1986
Heme enzyme patterns in genetically and chemically induced mouse liver tumors.
Chemically induced rat hepatocyte nodules and hepatomas have repeatedly been shown to be deficient in Phase I drug-metabolizing… 
1985
1985
Isolation of recombinant cDNAs encoding chicken erythroid delta-aminolevulinate synthase.
We report the isolation of cDNA clones encoding delta-aminolevulinate synthase (ALA synthase; EC 2.3.1.37), the first enzyme in… 
1981
1981
Biosynthesis of porphyrin precursors in mammals. Identity of alanine: gamma, delta-dioxovalerate aminotransferase with alanine:glyoxylate aminotransferase.
1980
1980
Metal ion interactions in the control of haem oxygenase induction in liver and kidney.
Mn2+ and Zn2+ exhibit a striking ability to block the induction by Sn2+ and Ni2+ of haem oxygenase (EC 1.14.99.3) in kidney. The… 
1976
1976
Synthesis of delta-aminolaevulinate synthase by isolated liver polyribosomes.
1. Postmitochondrial supernatants were prepared from the livers of chick embryos and were incubated under conditions that… 
1975
1975
Effect of cobalt on heme biosynthesis in rat liver and spleen.
1. Succinate-cytochrome c reductase activity in rat liver decreased to about 60% of the control value after a single injection of… 
1974
1974
Chlorophyll synthesis and intracellular fluctuations of 5-aminolaevulinate formation during the regreening of nitrogen-deficient Chlorella fusca.
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